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A. Young, M. Jiang, N. B. Akhmedov, D. B. Farber; Specific Interaction of the OA1 GPCR With the Gi3 Protein. Invest. Ophthalmol. Vis. Sci. 2010;51(13):5976.
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© ARVO (1962-2015); The Authors (2016-present)
Ocular albinism type 1 (OA1) is characterized by abnormalities in retinal pigment epithelium (RPE) melanosomes and misrouting of optic axons. This disease is caused by mutations in the OA1 gene, which encodes a melanosomal G-protein coupled-receptor (GPCR). We have shown before that Gαi3 signals in the same pathway as OA1. The purpose of this study is to demonstrate that Gαi3 interacts with Oa1.
Our in vitro experiments corroborate our previous studies that showed that Oa1 and Gαi3 signal in the same pathway demonstrating that Gαi3 protein specifically binds to the GPCR Oa1.
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