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D. J. Jacobs, T. Leng, D. Miller, H. W. Flynn, Jr., S. J. Gedde; Delayed-Onset, Bleb-Associated Endophthalmitis: How Are Causative Organisms Associated With Visual Acuity Outcomes?. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6038.
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To report causative organisms and the associated visual acuity outcomes in patients with delayed-onset, bleb-associated endophthalmitis.
Retrospective consecutive case series. Patients who were treated at the Bascom Palmer Eye institute for delayed-onset, bleb-associated endophthalmitis between January 1, 1996 through July 1, 2008 were included in this study. Culture results and visual acuity outcomes were analyzed.
A total of 65 eyes from 63 patients were identified. 85% (55/65) had positive intraocular cultures, and 15% (10/65) were culture negative. 14% (9/65) had polymicrobial infections. All organisms were sensitive to the intravitreal antibiotics clinically administered. Visual acuity outcomes of ≥20/400 were achieved in the following percentages of eyes: 40% (8/20) with Streptococcus species, 73% (8/11) with coagulase-negative Staphylococcus, 63% (5/8) with Staphylococcus aureus, 20% (1/5) with Enterococcus species, 80% (4/5) with Moraxella species, 25% (1/4) with Pseudomonas aeruginosa, 50% (4/8) with other gram-negative bacteria, and 70% (7/10) of culture negative eyes.
In the current study, better visual acuity outcomes were associated with Staphylococcal species, Moraxella species, and culture negative eyes compared to eyes with Streptococcus species, Enterococcus species, and Pseudomonas aeruginosa.
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