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Q. Ghadiali, M. A. William, H. F. Fine, J. L. Prenner; Non-Infectious Endophthalmitis (NIE) After Intravitreal Ranibizumab. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6055.
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To report multiple cases of NIE after intravitreal injection of ranibizumab.
Retrospective case series.
Three cases of NIE were discovered after injection of intravitreal ranibizumab over a one year time period. Eyes presented with marked anterior chamber cellular reaction, corneal endotheliitis, but only a mild pseudogranulomatous vitritis. All eyes had been previously treated with ranibizumab (average 10.6). Patients presented quickly after injection (4.3 days) with reports of visual loss and mild pain. Topical steroids were utilized as monotherapy and all eyes returned to baseline visual acuity by day 30.
NIE has been well documented after intravitreal bevacizumab. This is the first report of NIE after ranibizumab. The predominantly anterior reaction and response to topical therapy are typical of NIE.
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