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C. Erb, K. Krause, A. Baumann, H. Dietze, R. Alten, M. Heinke; Has Rheumatoid Arthritis an Influence on the Biomechanics of the Cornea?. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6251.
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Important ocular manifestations of rheumatoid arthritis (RA) are keratokonjunctivitis sicca, keratitis, episcleritis and scleritis. Ocular involvement is typical for a long disease duration of RA and a positive verification of rheumatoid factor. The aim of this study was to prove whether patients with a disease duration of more than 10 years of RA show changes concerning the biomechanics of the cornea because of collagen remodeling processes.
Thirtyeight patients with RA (f:m = 31:7, average of age ± standard deviation 57.47±5.04 years, duration of RA > 10 years) randomized with a control group of 41 healthy subjects (f:m = 31:10, 55.24±3.39 years) were included in this study. Besides a complete ocular examination, we performed the measurement of the corneal thickness without using the acoustic equivalent factor with the Orbscan II (Bausch&Lomb, USA), and the corneal hysteresis (CH) and the corneal resistance factor (CRF) with the Ocular Response Analyzer (ORA, Reichert Ophthalmic Instruments, USA).
The central corneal thickness of patients with RA showed an average of 584 ± 37.44 µm (mean±standard deviation). There was no significant difference according the control group (571 ± 38.49 µm). In addition no statistical significant difference of the corneal hysteresis and corneal resistance factor were found between the two tested groups (mean ± standard deviation, CH RA 11.74±1.35mm Hg; control group (C) 11.32±1.46mm Hg; CRF: RA 11.74±1.35mm Hg, C 11.32±1.46mm Hg).
Despite the long duration of RA (> 10 years) we could not find any changes of the corneal biomechanics concerning collagenosis.
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