April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Cross-Over Evaluation of Two Polyethylene Glycol 400 0.4% Artificial Tears in Mild Dry Eye Patients
Author Affiliations & Notes
  • A. D. Wasmanski
    Hazleton Eye Specialists, Bear Creek Twp., Pennsylvania
  • T. Kislan
    Hazleton Eye Specialists, Bear Creek Twp., Pennsylvania
  • Footnotes
    Commercial Relationships  A.D. Wasmanski, None; T. Kislan, None.
  • Footnotes
    Support  Unrestricted Grant
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 6263. doi:
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      A. D. Wasmanski, T. Kislan; Cross-Over Evaluation of Two Polyethylene Glycol 400 0.4% Artificial Tears in Mild Dry Eye Patients. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6263.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the efficacy of two Polyethylene Glycol 400 0.4% artificial tears for the treatment of mild dry eye signs and symptoms.

Methods: : Randomized, investigator-masked cross-over evaluation of 40 patients (80 eyes). Included patients were those with mild dry eye symptoms per patient reporting/physician assessment and were not currently using any artificial tears regularly, or using low viscosity tears for symptom relief (Refresh Tears, Visine Tears, Tears Naturelle, etc.). Patients were randomized to instill either Tear A (Blink tears, Abbott Medical Optics Inc.) or Tear B (Systane Ultra) in each eye four times-daily for 1 month. Patients were crossed-over after 1 month to the other drop. Study visits were at baseline, month 1, and month 2. Outcome measures included TBUT, VA and lissamine green staining and patients completed a dry eye questionnaire.

Results: : Tear A significantly improved TBUT after one month of treatment (increase of 2.4 seconds, P=.003) while there was no significant improvement with Tear B (increase of 0.3 seconds, P=.320). No significant changes were noted for staining or visual acuity. Patients reported that blink was more soothing, improved vision, was less blurring, and was more comfortable than Tear B (P≤.043).

Conclusions: : Tear A improved TBUT and the symptoms of dry eye significantly better than Systane Ultra. Patients preferred Tear A.

Clinical Trial: : www.clinicaltrials.gov NCT00493662

Keywords: cornea: tears/tear film/dry eye 

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