April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Characterization of an Anionic Lipid Stabilized Ocular Emulsion Containing HP-Guar
Author Affiliations & Notes
  • H. A. Ketelson
    R & D, Alcon Research Ltd, Fort Worth, Texas
  • J. Davis
    R & D, Alcon Research Ltd, Fort Worth, Texas
  • D. Meadows
    R & D, Alcon Research Ltd, Fort Worth, Texas
  • Footnotes
    Commercial Relationships  H.A. Ketelson, Alcon Inc., E; J. Davis, Alcon, E; D. Meadows, Alcon, Inc., E.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 6264. doi:
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      H. A. Ketelson, J. Davis, D. Meadows; Characterization of an Anionic Lipid Stabilized Ocular Emulsion Containing HP-Guar. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6264.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To study the physico-chemical properties of a novel artificial tear emulsion product technology based on an anionic phospholipid, mineral oil, HP-Guar and the demulcent propylene glycol. Adhesion, spreading pressures, steady state flow rheology and friction measurements were used to evaluate the emulsions for use as a restorative tear replacement eye drop displaying ocular surface protectant benefits.

Methods: : The emulsions were formed using mineral oil and a novel blend of interfacial substances with processing via in-line homogenization. Emulsions were adjusted to pH’s between 7-8. Adhesion and spreading experiments were evaluated by Langmuir Trough, elipsometry and light microscopy. Steady state flow and dynamic rheology profiles were obtained using a controlled state rheometer. Friction coefficients were measured using a pin-on-disc tribometer with pericardium tissue as the substrate.

Results: : Contact angle measurements indicated that the liquid/vapor surface tensions of the emulsions varied between approximately 70 mNm-1 at pH 7 to 56 mNm-1 at pH 8. The maximum estimated spreading pressures for the o/w emulsion were between 6-8 mNm-1. The emulsions at elevated pH (>7.4) displayed thixotropic behavior. For example, steady state flow experiments on emulsions at pH’s > 7.4 showed that that the viscosity decreased from 146 cps to 4.6 cps as the shear rate increased from 0.01s-1 to 1s-1, respectively. The emulsions also showed significant reductions in their coefficients of friction. For example, the friction coefficients for the emulsions were less than 0.1 for pH’s greater than 7.4.

Conclusions: : The data showed that a stable oil-water emulsion containing HP-Guar, an anionic phospholipid and a demulcent can be generated as a novel artificial tear product. The artificial tear product has a novel composition blend to provide ocular surface protectant properties.

Keywords: cornea: tears/tear film/dry eye 

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