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J. Wang, T. M. Conway, Y. Yuan, M. Shen, L. Cui; Tear Meniscus Volume Measured With Ultra-High Resolution OCT in Dry Eye After Restasis Treatment. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6266.
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It has been documented that artificial tears do not lead to sustained increases in tear volume, as blinking returns tear volume to baseline within 30 minutes post artificial tear instillation. This study was designed to evaluate if Restasis (0.05% cyclosporine) increases the tear meniscus volume, as measured with ultra-high resolution optical coherence tomography (OCT).
An ultra-high resolution (~3 µm) spectral domain OCT was used to image the upper and lower tear menisci (height, cross-sectional area, volume) in 7 consecutive dry eye patients at baseline. Key inclusion criteria: dry eye symptoms and signs (Schirmer ≤ 5 mm, staining ≥1, or TBUT ≤10 s); exclusion: prior use of Restasis. All patients were initiated on Restasis BID and measurements were repeated at 1 and 2 months while on treatment. All measurements were performed two hours after Restasis instillation and immediately after a blink.
The mean patient age was 38.1 ± 13.7 yrs and 5 out of 7 were male. The baseline tear meniscus volumes were 0.37 ± 0.14 µl (upper) and 0.42 ± 0.17 µl (lower). Each of the tear meniscus parameters (height, area, volume) in both eyes showed significant increases after 2 months on Restasis (P<0.05). At two months, the upper and lower tear meniscus volumes were 0.56 ± 0.24 µl and 0.61 µl ± 0.24 µl.
A measurable increase in tear meniscus volume was evident after two months of treatment with Restasis in dry eye patients. Anterior segment OCT offers a promising tool for diagnosing and monitoring dry eye treatment.
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