April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Tear Meniscus Volume Measured With Ultra-High Resolution OCT in Dry Eye After Restasis Treatment
Author Affiliations & Notes
  • J. Wang
    Ophthalmology, Bascom Palmer Eye Inst Lib, Miami, Florida
  • T. M. Conway
    Medical Affairs, Allergan, Inc, Irvine, California
  • Y. Yuan
    Ophthalmology, Bascom Palmer Eye Inst Lib, Miami, Florida
  • M. Shen
    Ophthalmology, Bascom Palmer Eye Inst Lib, Miami, Florida
  • L. Cui
    Ophthalmology, Bascom Palmer Eye Inst Lib, Miami, Florida
  • Footnotes
    Commercial Relationships  J. Wang, Allergan, F; T.M. Conway, Allergan, E; Y. Yuan, None; M. Shen, None; L. Cui, None.
  • Footnotes
    Support  Allergan research grant
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 6266. doi:
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      J. Wang, T. M. Conway, Y. Yuan, M. Shen, L. Cui; Tear Meniscus Volume Measured With Ultra-High Resolution OCT in Dry Eye After Restasis Treatment. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6266.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : It has been documented that artificial tears do not lead to sustained increases in tear volume, as blinking returns tear volume to baseline within 30 minutes post artificial tear instillation. This study was designed to evaluate if Restasis (0.05% cyclosporine) increases the tear meniscus volume, as measured with ultra-high resolution optical coherence tomography (OCT).

Methods: : An ultra-high resolution (~3 µm) spectral domain OCT was used to image the upper and lower tear menisci (height, cross-sectional area, volume) in 7 consecutive dry eye patients at baseline. Key inclusion criteria: dry eye symptoms and signs (Schirmer ≤ 5 mm, staining ≥1, or TBUT ≤10 s); exclusion: prior use of Restasis. All patients were initiated on Restasis BID and measurements were repeated at 1 and 2 months while on treatment. All measurements were performed two hours after Restasis instillation and immediately after a blink.

Results: : The mean patient age was 38.1 ± 13.7 yrs and 5 out of 7 were male. The baseline tear meniscus volumes were 0.37 ± 0.14 µl (upper) and 0.42 ± 0.17 µl (lower). Each of the tear meniscus parameters (height, area, volume) in both eyes showed significant increases after 2 months on Restasis (P<0.05). At two months, the upper and lower tear meniscus volumes were 0.56 ± 0.24 µl and 0.61 µl ± 0.24 µl.

Conclusions: : A measurable increase in tear meniscus volume was evident after two months of treatment with Restasis in dry eye patients. Anterior segment OCT offers a promising tool for diagnosing and monitoring dry eye treatment.

Clinical Trial: : www.clinicaltrials.gov NCT00706940

Keywords: anterior segment • lacrimal gland 
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