April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Acute Effects of Hemodialysis on Tear Fluid Secretion
Author Affiliations & Notes
  • M. Nakata
    Ophthalmology, Wakayama Medical University, Wakayama, Japan
  • Y. Okada
    Ophthalmology, Wakayama Medical University, Wakayama, Japan
  • H. Kobata
    Dialysis Kidney Center, Nate Hospital, Kinokawa, Japan
  • S. Saika
    Ophthalmology, Wakayama Medical University, Wakayama, Japan
  • Footnotes
    Commercial Relationships  M. Nakata, None; Y. Okada, None; H. Kobata, None; S. Saika, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 6273. doi:
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      M. Nakata, Y. Okada, H. Kobata, S. Saika; Acute Effects of Hemodialysis on Tear Fluid Secretion. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6273.

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Abstract

Purpose: : To investigate the acute effects of hemodialysis (HD) on tear fluid secretion. Although it is known that tear fluid secretion is attenuated in patients with chronic renal failure, the alteration of tear fluid secretion before and just after hemodialysis has not yet been fully studied.

Methods: : Seventy-one eyes of thirty-six patients (Male: female = 26: 51) were included in the study. Patients ranged from 42 to 87 yearsold (mean; 68.9 +/- 10.2 yearsold). Upon informed consent was obtained from each patient, tear secretion was examined using Shirmer I test before and just after HD. Relation between the alteration in tear secretion and chronic renal failure (CRF)-related variables (age, serum creatinine level, duration of HD, the volume of fluid extracted during hemodialysis, diabetes mellitus) was statistically examined.

Results: : The Schirmer value did not significantly change after HD in any patient. The patients were then grouped in three categories; Group 1 (Schirmer value increased over 3. 0mm after HD.); group II (Schirmer value unchanged after HD); group III (Schirmer value decreased over 3.0 mm after HD). Among CRF-related variables examined, Schirmer value before HD in group III was in the normal range and was significantly higher than those in groups I and II. The number of diabetic patients was significantly greater in group III, but not in groups I and II.

Conclusions: : Tear fluid secretion is reduced by HD in patients with a normalrange of tear secretion before HD. The tendency was more frequently observed in patients with CRF due to diabetes mellitus.

Keywords: lacrimal gland • clinical (human) or epidemiologic studies: risk factor assessment • cornea: tears/tear film/dry eye 
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