April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Visual Function and Cortical Organization in Carriers of Blue Cone Monochromacy
E. A. Rossi; R. L. Achtman; A. Guidon; D. R. Williams; A. Roorda; D. Bavelier; J. Carroll
Author Affiliations & Notes
  • E. A. Rossi
    Vision Science Graduate Group, Rochester Center for Brain Imaging, Department of Ophthalmology,
    University of California, Berkeley, Berkeley, California
  • R. L. Achtman
    Vision Science Graduate Group, Rochester Center for Brain Imaging, Department of Ophthalmology,
    Department of Psychology, Nazareth College, Rochester, New York
    University of Rochester, Rochester, New York
  • A. Guidon
    Vision Science Graduate Group, Rochester Center for Brain Imaging, Department of Ophthalmology,
    University of Rochester, Rochester, New York
    Brain Imaging and Analysis Center, Duke University, Durham, North Carolina
  • D. R. Williams
    School of Optometry, Center for Visual Science, Department of Cell Biology, Neurobiology, & Anatomy,
    University of Rochester, Rochester, New York
  • A. Roorda
    Vision Science Graduate Group, Rochester Center for Brain Imaging, Department of Ophthalmology,
    School of Optometry, Center for Visual Science, Department of Cell Biology, Neurobiology, & Anatomy,
    University of California, Berkeley, Berkeley, California
  • D. Bavelier
    Vision Science Graduate Group, Rochester Center for Brain Imaging, Department of Ophthalmology,
    Department of Brain and Cognitive Sciences,
    University of Rochester, Rochester, New York
  • J. Carroll
    Vision Science Graduate Group, Rochester Center for Brain Imaging, Department of Ophthalmology,
    School of Optometry, Center for Visual Science, Department of Cell Biology, Neurobiology, & Anatomy,
    Medical College of Wisconsin, Milwaukee, Wisconsin
  • Footnotes
    Commercial Relationships  E.A. Rossi, None; R.L. Achtman, None; A. Guidon, None; D.R. Williams, Optos, C; U.S. Patents #5,777,719, #5,949,521, #6,095,651, #6,379,005, #6,948,818, #6,199,986, #6,299,311, #6,827,444, #6,264,328, #6,338,559, P; A. Roorda, U.S. Patent #7,118,216, P; D. Bavelier, None; J. Carroll, None.
  • Footnotes
    Support  NIH Grant's EY001319, EY014375, EY001931, EY017607, Research to Prevent Blindness, and the NSF Center for Adaptive Optics under cooperative agreement AST-9876783 managed by UC Santa Cruz
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 6297. doi:
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      E. A. Rossi, R. L. Achtman, A. Guidon, D. R. Williams, A. Roorda, D. Bavelier, J. Carroll; Visual Function and Cortical Organization in Carriers of Blue Cone Monochromacy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6297.

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Abstract

Purpose: : Carriers of blue cone monochromacy (BCM) have previously been shown to have on average 50% fewer cone photoreceptors than normal. The purpose of this study was to examine the effect of this cone loss on visual function and cortical organization.

Methods: : Visual acuity was measured at the preferred retinal locus of fixation (PRLF) and two eccentric locations (2.5° and 8°) with spectacle correction only. Adaptive optics (AO) corrected visual acuity and cone spacing was simultaneously measured at locations within the central fovea (0-2.5°) using adaptive optics scanning laser ophthalmoscopy (AOSLO). The area of the foveal confluence was measured using retinotopic mapping techniques in fMRI.

Results: : Although carriers appeared within the normal range for acuity measurements without AO correction, visual acuity testing in AOSLO revealed significantly reduced visual resolution in carriers compared to normal observers. No difference was found in the area of the foveal confluence in carriers compared to normal controls.

Conclusions: : Reduced AO corrected resolution in the BCM carriers could not be explained by cone loss alone. The observed reduction in AO corrected acuity in the carriers suggested a loss of retinal ganglion cells (RGCs). However, the loss of RGCs in the BCM carriers did not result in a change in foveal confluence area. This suggests that an independent factor regulates the size of the cortical representation.

Keywords: retina: proximal (bipolar, amacrine, and ganglion cells) • photoreceptors: visual performance • visual cortex 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
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