April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Quantitative Correlation of Macular Structure by OCT-SLO With Function Using 3-D Computerized Threshold Amsler Grid in Age-Related Macular Degeneration and Macular Pucker
C. D. Robison; M. Y. Wang; L. M. Cuzzo; M. Niemeyer; W. Fink; A. A. Sadun; J. Sebag
Author Affiliations & Notes
  • C. D. Robison
    VMR Institute, Huntington Beach, California
    Doheny Eye Institute, Keck School of Medicine of USC, Los Angeles, California
  • M. Y. Wang
    VMR Institute, Huntington Beach, California
    Doheny Eye Institute, Keck School of Medicine of USC, Los Angeles, California
  • L. M. Cuzzo
    VMR Institute, Huntington Beach, California
    Doheny Eye Institute, Keck School of Medicine of USC, Los Angeles, California
  • M. Niemeyer
    VMR Institute, Huntington Beach, California
    Heidelberg University, Heidelberg, Germany
  • W. Fink
    Visual and Autonomous Exploration Systems Research Laboratory, California Institute of Technology, Pasadena, California
    Depts. of Electrical & Computer Engineering and Biomedical Engineering, University of Arizona, Tucson, Arizona
  • A. A. Sadun
    Doheny Eye Institute, Keck School of Medicine of USC, Los Angeles, California
  • J. Sebag
    VMR Institute, Huntington Beach, California
    Doheny Eye Institute, Keck School of Medicine of USC, Los Angeles, California
  • Footnotes
    Commercial Relationships  C.D. Robison, None; M.Y. Wang, None; L.M. Cuzzo, None; M. Niemeyer, None; W. Fink, Patent Holder, P; A.A. Sadun, Patent Holder, P; J. Sebag, None.
  • Footnotes
    Support  VMR Consulting, Inc., Research to Prevent Blindness, National Eye Institute Grant EY03040
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 6319. doi:
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      C. D. Robison, M. Y. Wang, L. M. Cuzzo, M. Niemeyer, W. Fink, A. A. Sadun, J. Sebag; Quantitative Correlation of Macular Structure by OCT-SLO With Function Using 3-D Computerized Threshold Amsler Grid in Age-Related Macular Degeneration and Macular Pucker. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6319.

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Abstract

Purpose: : To correlate central retinal structure with macular function in patients with macular pucker (MP) or age-related macular degeneration (AMD). It was hypothesized that volumetric assessments of macular structure would correlate with 3-dimensional contrast visual field evaluations of macular function in MP and wet AMD, but not dry AMD and controls.

Methods: : Structure was evaluated using combined Optical Coherence Tomography-Scanning Laser Ophthalmoscopy (OCT-SLO, OPKO-OTI, Inc). Macular function was assessed with 3-D Computerized Threshold Amsler Grid (3D-CTAG; Fink & Sadun, J Biomed Opt 2004) that evaluates the central visual field at different contrasts.Eighty-one eyes (34 Dry AMD, 8 wet AMD, 12 MP, 27 controls) were tested with OCT-SLO and 3D-CTAG at 5 contrast levels (5%, 10%, 20%, 40%, and 100%).OCT-SLO indices of macular structure were Total Average Thickness (µm) and Total Volume (µL). 3D-CTAG indices of macular function were Volume Lost with Respect to Normal Hill-of-Vision (% Volume Lost) and Lost Area Grade (LAG) = (scotoma area at highest tested contrast level/scotoma area at lowest tested contrast level) x scotoma depth [%].

Results: : MP eyes had a strongly positive correlation between function and structure when % Volume Lost (determined by 3D-CTAG) was compared to Total Average Thickness (r = 0.78, p < 0.0001) and Total Volume (r = 0.78, p < 0.0001) as measured by OCT-SLO.Wet AMD had a strongly positive correlation between function and structure when LAG was compared to Total Average Thickness (r = 0.84, p < 0.0004) and Total Volume (r = 0.84, p < 0.0001) as well as when Total Volume was compared to % Volume Lost (r = 0.45, p < 0.01).Dry AMD and Controls had no significant correlations.

Conclusions: : 3D-CTAG quantification of macular function in MP and wet AMD strongly correlates with structural assessment of macular thickness and volume. The positive correlation between 3D-CTAG and OCT-SLO demonstrates 3D-CTAG’s utility as both a qualitative and quantitative method of characterizing the impact of disease on macular function. Thus 3D-CTAG can provide a useful quantitative functional outcome measure of therapy.

Keywords: age-related macular degeneration • macula/fovea • contrast sensitivity 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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