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C. D. Robison, M. Y. Wang, L. M. Cuzzo, M. Niemeyer, W. Fink, A. A. Sadun, J. Sebag; Quantitative Correlation of Macular Structure by OCT-SLO With Function Using 3-D Computerized Threshold Amsler Grid in Age-Related Macular Degeneration and Macular Pucker. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6319.
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To correlate central retinal structure with macular function in patients with macular pucker (MP) or age-related macular degeneration (AMD). It was hypothesized that volumetric assessments of macular structure would correlate with 3-dimensional contrast visual field evaluations of macular function in MP and wet AMD, but not dry AMD and controls.
Structure was evaluated using combined Optical Coherence Tomography-Scanning Laser Ophthalmoscopy (OCT-SLO, OPKO-OTI, Inc). Macular function was assessed with 3-D Computerized Threshold Amsler Grid (3D-CTAG; Fink & Sadun, J Biomed Opt 2004) that evaluates the central visual field at different contrasts.Eighty-one eyes (34 Dry AMD, 8 wet AMD, 12 MP, 27 controls) were tested with OCT-SLO and 3D-CTAG at 5 contrast levels (5%, 10%, 20%, 40%, and 100%).OCT-SLO indices of macular structure were Total Average Thickness (µm) and Total Volume (µL). 3D-CTAG indices of macular function were Volume Lost with Respect to Normal Hill-of-Vision (% Volume Lost) and Lost Area Grade (LAG) = (scotoma area at highest tested contrast level/scotoma area at lowest tested contrast level) x scotoma depth [%].
MP eyes had a strongly positive correlation between function and structure when % Volume Lost (determined by 3D-CTAG) was compared to Total Average Thickness (r = 0.78, p < 0.0001) and Total Volume (r = 0.78, p < 0.0001) as measured by OCT-SLO.Wet AMD had a strongly positive correlation between function and structure when LAG was compared to Total Average Thickness (r = 0.84, p < 0.0004) and Total Volume (r = 0.84, p < 0.0001) as well as when Total Volume was compared to % Volume Lost (r = 0.45, p < 0.01).Dry AMD and Controls had no significant correlations.
3D-CTAG quantification of macular function in MP and wet AMD strongly correlates with structural assessment of macular thickness and volume. The positive correlation between 3D-CTAG and OCT-SLO demonstrates 3D-CTAG’s utility as both a qualitative and quantitative method of characterizing the impact of disease on macular function. Thus 3D-CTAG can provide a useful quantitative functional outcome measure of therapy.
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