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D. Callanan, Luminate Study Group; Correlation Between Vitreous Haze and Visual Acuity in Patients Treated With LX211 (LuveniqTM/Voclosporin Oral Capsule) in an Active Uveitis Affecting the Posterior Segment. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6377.
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© ARVO (1962-2015); The Authors (2016-present)
Assess correlation between Ocular Inflammation and Vision as measured by Vitreous Haze and BCVA in patients treated with LX211 (LuveniqTM/voclosporin oral capsule) for active posterior non-infectious uveitis.
Study LX211-01 assessed the response of LX211 in patients with active posterior-segment disease with mean change in vitreous haze as the primary endpoint. BCVA was assessed as a safety parameter. Vitreous haze was measured by the SUN Working Group ordinal scale and vision was assessed using ETDRS. Change in inflammation versus change in visual acuity score within the 6-month study period was plotted.
218 patients were enrolled in the LX211-01 study. Patients in the LX211-01 protocol had a mean vitreous haze (VH) score of 2.1 at baseline; mean decrease in VH in the 0.4 mg/kg BID LX211 treatment group at Week 24 was -1.1, statistically significant compared to placebo. Visual Acuity in the LX211-01 was preserved in all treatment groups with mean change in visual acuity from baseline ranging from -0.5 in the 0.2 mg/kg BID LX211 treatment group to +1.5 in the 0.6 mg/kg BID LX211 dose group. Changes in VH ranged from -3.0 and +2.0. Change in VH of -3.0, -2.0, -1.0, 0.0, +1.0, +2.0 correlated to a mean change in BCVA of 2.6, 6.0, 3.1, 0.8, -17.7, -5.0, respectively.
A decline in vitreous haze was associated with minor improvement in vision while an increase in inflammation was associated with a major decrease in vision. Control of inflammation is paramount to preserve visual acuity in noninfectious uveitis patients.
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