April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Adverse Effects of Smoking on Patients with Ocular Inflammation
Author Affiliations & Notes
  • A. Galor
    Ophthalmology, Bascom Palmer, Miami, Florida
  • W. Feuer
    Ophthalmology, Bascom Palmer, Miami, Florida
  • J. H. Kempen
    Ophthalmology/Biostatistics&Epidemiology, Scheie Eye Inst/Univ of Penn, Philadelphia, Pennsylvania
  • E. B. Suhler
    Uveitis Clinic, Casey Eye Institute-OHSU/Portland VAMC, Portland, Oregon
  • C. Foster
    Ophthalmology, Ocular Immunology and Uveitis Foundation, Cambridge, Massachusetts
  • D. A. Jabs
    Ophthalmology, Mount Sinai School of Medicine, New York, New York
  • G. A. Levy-Clarke
    St Lukes Cataract and Laser Institute, St Petersburg, Florida
  • R. B. Nussenblatt
    National Eye Inst/NIH, Bethesda, Maryland
  • J. T. Rosenbaum
    Ophthalmology, Casey Eye Institute-OHSU, Portland, Oregon
  • J. E. Thorne
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  A. Galor, None; W. Feuer, None; J.H. Kempen, None; E.B. Suhler, None; C. Foster, None; D.A. Jabs, None; G.A. Levy-Clarke, None; R.B. Nussenblatt, None; J.T. Rosenbaum, None; J.E. Thorne, None.
  • Footnotes
    Support  EY014943; P30 EY014801; Research to Prevent Blindness; intramural funds of NEI; US Department of Veterans’ Affairs
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 6379. doi:
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      A. Galor, W. Feuer, J. H. Kempen, E. B. Suhler, C. Foster, D. A. Jabs, G. A. Levy-Clarke, R. B. Nussenblatt, J. T. Rosenbaum, J. E. Thorne; Adverse Effects of Smoking on Patients with Ocular Inflammation. Invest. Ophthalmol. Vis. Sci. 2010;51(13):6379.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate how smoking affects the time-to-disease quiescence and time-to-disease recurrence in patients with ocular inflammation.

Methods: : Retrospective cohort study of patients with ocular inflammation who were followed longitudinally and had smoking information available in the Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study database.

Results: : Among 2,676 patients with active ocular inflammation, smokers were more likely to have bilateral ocular disease and poorer visual acuity on presentation compared to nonsmokers and previous smokers. In a multivariate analysis, there was no statistically significant difference in the time-to-disease quiescence between groups. However, the median time-to-recurrence of ocular inflammation was statistically significantly longer for nonsmokers (9.4 months) and for previous smokers (10.7 months) than for current smokers (7.8 months) (p= 0.02). The relative risk of ocular inflammation recurrence was higher for smokers than nonsmokers (adjusted HR=1.19, 95% CI 1.03-1.37) and tended towards significant in previous smokers (adjusted HR=1.11, 95% CI 0.93-1.35).

Conclusions: : Smoking was associated with an increased likelihood of bilateral ocular inflammation and reduced vision upon presentation, and an increased risk of recurrence compared to nonsmokers. These results suggest that ocular inflammation patients should be counseled to stop smoking as part of routine management.

Keywords: uveitis-clinical/animal model • clinical (human) or epidemiologic studies: risk factor assessment • inflammation 

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