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T. P. Kislan, F. A. Bucci, Jr.; A Comparison of Silcone Hydrogel vs. Specialty Dry Eye Contact Lenses in Previous Dry Eye Patients With and Without Restasis Treatment. Invest. Ophthalmol. Vis. Sci. 2008;49(13):101.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the performance of the silicone hydrogel contact lens Acuvue Advance (AA) with that of the specialty dry eye contact lenses Proclear Biocompatible (PB) and Extreme H20 Extra (EE) in dry eye patients with and without RESTASIS® use.
105 dry eye patients reporting ocular surface discomfort with their present spherical contact lenses were enrolled in this investigator-masked study. Exclusion criteria included patients presenting with use of RESTASIS, omega fatty acids, punctal occlusion, PB, EE, or silicone hydrogels. After a 2-week wash out with REFRESH TEARS® QID, all patients were fit with AA lenses OD and randomized to the following lenses OS: Group A1, PB (n=27); A2, EE (n=26); B1, PB (n=26); B2, EE (n=26). Groups A1 and A2 could use REFRESH TEARS® as needed; Groups B1 and B2 were instructed to use RESTASIS® BID in both eyes and not to use any artificial tears. Outcome measures: Schirmer scores, tear break-up time (TBUT), and patient assessment of lens wear-time and comfort. Follow-up visits: week 1, and months 1, 3, and 6.
All study lenses outperformed the patient’s previous lenses for all outcome measures (p ≤ .001) by 1 month. The performance of the specialty dry eye lenses, PB and EE, was similar, however both outperformed the silicone hydrogel lens, AA, for all outcome measures (p≤.007) by 3 months. Across all lens types, RESTASIS® use produced significantly more favorable outcomes on all measures by 1 month (p ≤.009).
1. All lens types outperformed the previous lens materials. 2. "Dry eye contact lens" (PB-omafilxon-A and EE-hioxifilcon-A) provided significantly more favorable comfort, wear time, Schirmer scores, and TBUT than did the use of silicone hydrogel lenses (AA-galyfilcon-A). 3. The performance of all study lens types was significantly improved by the concomitant use of RESTASIS®.
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