May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
A Simple and Evolutional Approach Proven to Re-Canalize the Nasolacrimal Duct Obstruction
Author Affiliations & Notes
  • Z. Wang
    Corneal Department, Zhongshan Ophthalmic Center, Guangzhou, China
  • D. Chen
    Department of E.N.T, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Footnotes
    Commercial Relationships  Z. Wang, None; D. Chen, None.
  • Footnotes
    Support  This work was supported by the grant No. 2004BA720A15 (WZC) from the National Key Technologies Research and Development Program of the Tenth Five-Year Plan.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 105. doi:
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      Z. Wang, D. Chen; A Simple and Evolutional Approach Proven to Re-Canalize the Nasolacrimal Duct Obstruction. Invest. Ophthalmol. Vis. Sci. 2008;49(13):105. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the long-term performance of re-canalization of nasolacrimal duct obstruction (RC-NLDO), a simple and evolutional approach, in the treatment of the nasolacrimal duct obstruction (NLDO) and chronic dacryocystitis.

Methods: : Long-term follow-up (up to 54 months) results between two groups of patients with RC-NLDO and external dacryocystorhinostomy (EX-DCR) were compared, and the histopathological examinations of RC-NLDO were performed in rhesus monkeys. One thousand and forty patients with 1147 eyes suffering from NLDO and chronic dacryocystitis were enrolled in this study. The RC-NLDO was performed in 1012 eyes as a study group, which was compared with 135 eyes underwent EX-DCR as a control group. Patients with surgical failures were offered a second surgery. Patient follow-up was evaluated by dye disappearance test, lacrimal irrigation and symptoms in all patients, and the digital subtraction dacryocystogram were performed in some patients. The RC-NLDO was performed in one eye of 12 animals and the other eyes were used as controls for pathological study. The animals were sacrificed immediately, 7 days, and 1-3 months after surgery for histopathological examination. The healing process and pathological changes of re-epithelization and infiltration of inflammatory cells were examined in nasolacrimal duct of rhesus monkey.

Results: : The clinical success rats were 93.1% in 1012 cases of RC-NLDO, and 91.11% in 135 cases of EX-DCR. The success rats for second surgery were achieved in 85.19% on RC-NLDO and 40.0% on EX-DCR. No major intra- or post-operative complications were observed in the RC-NLDO group. Mild postoperative bleeding occurred in 1 case (0.74%) and transient pain occurred in 8 cases (5.93%) in the EX-DCR group. The mean operative duration was 12.5 minutes for RC-NLDO while 40.3 minutes for EX-DCR (P<0.001). Pathological study in rhesus monkeys demonstrated that the RC-NLDO wounded epithelium in nasolacrimal duct healed completely within 1 month without granulation tissue formation.

Conclusions: : Our findings demonstrated that this new approach of RC-NLDO was proven to re-canalize the obstructed nasolacrimal duct with a comparable success rate to EX-DCR, and it may be an optimal choice for recurrent patients with NLDO and chronic dacryocystitis.

Keywords: lacrimal gland 

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