May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
A Comparison of Comfort/Acceptability and Blur Profile Between PEG/PG and CMC/Glycerin Based Artificial Tears in Both a Dry Eye and Non-Dry Eye Patient Populations
Author Affiliations & Notes
  • M. T. Christensen
    Consumer Products Clinical, Alcon Research, Ltd., Fort Worth, Texas
  • A. E. Martin
    Consumer Products Clinical, Alcon Research, Ltd., Fort Worth, Texas
  • R. E. David
    Consumer Products Clinical, Alcon Research, Ltd., Fort Worth, Texas
  • Footnotes
    Commercial Relationships  M.T. Christensen, Alcon Research LTD, E; A.E. Martin, Alcon Research LTD, E; R.E. David, Alcon Research LTD, E.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 109. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. T. Christensen, A. E. Martin, R. E. David; A Comparison of Comfort/Acceptability and Blur Profile Between PEG/PG and CMC/Glycerin Based Artificial Tears in Both a Dry Eye and Non-Dry Eye Patient Populations. Invest. Ophthalmol. Vis. Sci. 2008;49(13):109. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To evaluate drop comfort, acceptability, preference and blur profile between two marketed artificial tears in both dry eye and non-dry eye patient populations.

Methods: : This was a controlled, randomized, single drop, acute, double masked, two-period crossover study. 40 patients who signed informed consent were enrolled (20 dry eye patients; 20 non-dry eye = normals). All patients received both products in a randomized fashion with a 24-hr washout between periods. Immediately following administration of the masked artificial tears by the study coordinator, patients were asked to complete a 3 minute blur profile by marking a visual analog scale (VAS) every 30 sec. Following the blur profile determination, patients were asked to evaluate drop comfort, drop acceptability and drop preference on a second VAS. A PEG/PG based tear (SYSTANE® Lubricant Eye Drops, Alcon) and a CMC/Glycerin based tear (Optive TM Lubricant Eye Drops, Allergan) were the comparative drops studied.

Results: : In the dry eye population, the PEG/PG based tear showed statistically significantly less blur at T0 and T30 sec but no statistical differences beyond those time points. The normal population was similar but with statistically significant differences through T60 sec (T0, T30 sec, T60 sec) with less blur for the PEG/PG based tear. Overall, there were no statistically significant differences between the two artificial tears on drop comfort, drop acceptability or drop preference. However, a trend was shown for better drop acceptability (p = 0.07) in the dry eye population for the PEG/PG tear, but was not considered clinically different.

Conclusions: : This acute study showed that these two marketed artificial tears (SYSTANE® and Optive TM) were well tolerated and similar in comfort and preference in both dry eye and normal patients. Findings further indicate that Systane exhibits significantly less blur at 30 and 60 seconds following drop administration than Optive TM . However, to assess maximum therapeutic benefit, additional studies need to be conducted to evaluate potential differences in clinical efficacy between these products.

Clinical Trial: : www.clinicaltrials.gov NCT00568386

Keywords: cornea: tears/tear film/dry eye • cornea: clinical science 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×