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A. H. Shaikh, Z. M. S. Corrêa, J. J. Augsburger; Relationship Between Reese-Ellsworth Classification and International Classification of Intraocular Retinoblastoma. Invest. Ophthalmol. Vis. Sci. 2008;49(13):13.
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To determine the relationship between the Reese-Ellsworth (RE) Classification and International Classification of Intraocular Retinoblastoma (ICIR) in a retrospective series.
The clinical records of 300 patients with retinoblastoma (RB) evaluated by the senior author (JJA) between 1980 and 2007 were reviewed. Patients who received any treatment prior to evaluation by senior author were excluded from the study (n=152). Fundus drawings, anterior segment drawings, and chart notations made by the senior author at baseline evaluation were reviewed, and the RE Classification and ICIR of each affected eye was determined retrospectively. Cross-tabulation of RE versus ICIR groups was prepared.
The 148 study cases included 101 (68.2%) unilateral and 47 (31.8%) bilateral RB (Total of 195 cases). The table bellow shows that a substantial number of eyes classified as RE group I and II were classified in a higher corresponding group in the ICIR. In contrast, a substantial number of eyes classified as RE group V were classified in a lower corresponding group in the ICIR. Most eyes classified as RE group III were classified in either a lower or higher ICIR group. Fewer than 10% of eyes were assigned to RE group IV or ICIR groups A and C in this series.
Although the RE classification and ICIR are both 5-group ordinal categorical classifications of affected eyes, the ICIR seems to provide better discrimination between severely affected but potentially salvageable eyes (Group D) and unsalvageable eyes (Group E) than does the RE classification.
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