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D. Denis, E. Toesca, E. Zanin, S. Guigou, N. Girard; Interest of Cerebral MRI in Infantile Nystagmus Syndrome. Invest. Ophthalmol. Vis. Sci. 2008;49(13):138.
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© ARVO (1962-2015); The Authors (2016-present)
infantile nystagmus syndrome (INS) may be present at birth but usually develops during infancy. The aim of this study was to present the results of MRI in the INS.
prospective study from 2000 to 2007 with inclusion of 75 patients presenting INS who also had cerebral MRI (average age of MRI: 12.50 months). Three groups of patients with INS were individualized: group 1 (n=34) - neurologic nystagmus (associated with neurological context: fetal suffering, psychomotor retardation, epilepsy.); group 2 (n=23) - sensory nystagmus (with disease of visual system), group 3 (n=18): isolated nystagmus (idiopathic and hereditary). Nystagmus (waveform, orientation) and MRI signs were analysed. MRI was read by a single neuroradiologist experienced in pediatric MRI (NG). MRI results were classified as follow: 1.ventricular dilatations, 2.enlarged subarachnoid and Virchow-Robin spaces, 3.white matter signal abnormalities, 4. hemispheric malformations (corpus callosum, septum pellucidum….), 5. brainstem abnormalities (including brainstem malformations), 6. cerebellar abnormalities.
the mean age of the onset of nystagmus was 2.8 months. The nystagmus was always conjugate and mainly horizontal 75%, vertical 18%, torsional 7%. The waveform of the nystagmus was pendular in 58%, jerk in 24%, combined pendular-jerk in 18%. MRI showed: 1. ventricular dilatations in 63% (of whom the nystagmus was neurologic in 56%, sensory in 28%, isolated in 16%); 2. enlarged subarachnoid and Virchow-Robin spaces in 70% (of whom the 57% neurologic, 25% sensory, 18% isolated); 3. white matter signal abnormalities in 55 % (of whom the nystagmus was neurologic in 64%, sensory in 18%, isolated in 18%); 4. hemispheric malformations in 15% (of whom the nystagmus was neurologic in 84%, sensory in 16%); 5. brainstem abnormalities in 45% (of whom the nystagmus was neurologic in 56%, sensory in 25%, isolated in 19%); cerebellar abnormalities in 38% (of whom the nystagmus was neurologic in 80%, sensory in 7%, isolated in 13%). MRI results according to the three groups showed a statistical correlation between the percentage of pathological MRI and each type of group of patients.
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