May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Association of LOC387715 A69S With Vitreous Hemorrhage in Polypoidal Choroidal Vasculopathy
Author Affiliations & Notes
  • Y. Sakurada
    Opthalmology, University of Yamanashi, chuo, Japan
  • M. Imasawa
    Opthalmology,
    University of Yamanashi, Chuo, Japan
  • T. Kubota
    Epigenetics,
    University of Yamanashi, Chuo, Japan
  • F. Mabuchi
    Opthalmology,
    University of Yamanashi, Chuo, Japan
  • N. Tanabe
    Opthalmology,
    University of Yamanashi, Chuo, Japan
  • H. Iijima
    Opthalmology,
    University of Yamanashi, Chuo, Japan
  • Footnotes
    Commercial Relationships  Y. Sakurada, None; M. Imasawa, None; T. Kubota, None; F. Mabuchi, None; N. Tanabe, None; H. Iijima, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 240. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Y. Sakurada, M. Imasawa, T. Kubota, F. Mabuchi, N. Tanabe, H. Iijima; Association of LOC387715 A69S With Vitreous Hemorrhage in Polypoidal Choroidal Vasculopathy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):240. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To investigate whether the LOC387715 polymorphism is associated with polypoidal choroidal vasculopathy (PCV) and with vitreous hemorrhage (VH), one of the most severe clinical phenotypes, in the Japanese population.

Methods: : One hundred and nine Japanese patients with PCV, comprised of 9 patients associated with VH (VH group) and 100 patients without VH (non-VH group), and 85 control subjects were analyzed for the LOC387715 polymorphism (rs = 10490924), using denaturing high performance chromatography.

Results: : There was a significant difference in the T allele frequency between PCV patients and control subjects (P < 0.001). In comparison with wild-type homozygosity (GG), homozygosity for the at-risk allele genotype (TT) increased the likelihood for PCV 8.4-fold (3.6 to 19.5, 95% confidence interval [CI]) and heterozygosity for the at-risk allele genotype (TG) increased the likelihood for PCV 4.0-fold (1.9 to8.4, 95% CI). There was a significant difference in the genotypic frequency at the LOC387715 site between the VH and non-VH groups (P = 0.0099, Chi-square test) with the TT genotype occurring in 88.9% in the VH group and 37.0% in the non-VH group. The frequency of the T allele in the VH group was significantly greater than that in the non-VH group (0.944 vs. 0.610, P = 0.0039, Fisher exact test).

Conclusions: : The LOC387715 polymorphism is associated with PCV and clinical severity in the subgroups of PCV in the Japanese population.

Keywords: age-related macular degeneration • genetics • vitreous 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×