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R. E. Frenkel, L. Mani, A. Reyes; Complications of a Surgeon’s Initial Intravitreal Injections. Invest. Ophthalmol. Vis. Sci. 2008;49(13):253.
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To determine the incidence of complications secondary to a surgeon’s initial consecutive 345 intravitreal injections
A retrospective study of a single surgeon’s first 345 intravitreal anti-VEGF injections, administered to exudative AMD patients was performed. 104 eyes received Macugen, 74 received Avastin, and 167 received Lucentis using different gauge needle. All patients received an average of 1 prophylactic medication one hour prior to the injections. Vision was evaluated immediately following injection.
All patients showed a significant increase in transient IOP 1" after injection which usually normalized by about 30" post-injection. 1 eye developed a lid swelling, 2 had transient pain during the injection, 1 eye acquired transient floaters, 1 eye suffered an RPE rip, 1 patient had corneal edema, and 1 got a corneal abrasion. There was a 4.8% (5/104) incidence of transient NLP following Macugen injections, while no patients went NLP following Avastin or Lucentis. None of the patients had retinal tear, heart attack, stroke, endophthalmitis, toxic reaction, traumatic cataracts, retinal detachment, or vitreous hemorrhage.
Surgeons initial intravitreal injections can be very safely perform with only minimal complications.
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