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A. Giuliano, A. Reyes, L. Mani, R. E. P. Frenkel, A. R. Toler, M. P. C. Frenkel; Does Central Corneal Thickness Change When IOP Significantly Increases?. Invest. Ophthalmol. Vis. Sci. 2008;49(13):277.
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To determine if the Central Corneal Thickness (CCT) changes with IOP spikes following intravitreal injections.
22 intravitreal injections were administered in patients with exudative AMD. All patients received an average of 1 prophylactic IOP lowering medications one hour prior to the intravitreal injection. Central corneal thickness measured by corneal pachymetry and IOP measured by Tonopen-2 were both taken before and 1" after intravitreal injections. All eyes were lubricated with sterile BSS post-injection to keep the cornea hydrated.
The Mean Pre injection IOP was 13 ± 4 mm Hg. The mean IOP at 3-10" post-injection was 27 ± 7 mmHg. Mean CCT pre injection was 542 µm and post injection was 510 µm (p-value = 0.13). There was no statistically significant difference in the mean CCT before and after injections in this pilot study, though a trend was established. Differences were noted that might be statistically significant with a larger sample size.
CCT measurements decreased with increasing IOP but not in a statistically significant fashion in this small study cohort.
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