May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Does Central Corneal Thickness Change When IOP Significantly Increases?
Author Affiliations & Notes
  • A. Giuliano
    East Florida Eye Institute, Stuart, Florida
  • A. Reyes
    Eye Research Foundation, Stuart, Florida
  • L. Mani
    Eye Research Foundation, Stuart, Florida
  • R. E. P. Frenkel
    East Florida Eye Institute, Stuart, Florida
  • A. R. Toler
    East Florida Eye Institute, Stuart, Florida
  • M. P. C. Frenkel
    Eye Research Foundation, Stuart, Florida
  • Footnotes
    Commercial Relationships  A. Giuliano, None; A. Reyes, None; L. Mani, None; R.E.P. Frenkel, None; A.R. Toler, None; M.P.C. Frenkel, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 277. doi:https://doi.org/
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    • Get Citation

      A. Giuliano, A. Reyes, L. Mani, R. E. P. Frenkel, A. R. Toler, M. P. C. Frenkel; Does Central Corneal Thickness Change When IOP Significantly Increases?. Invest. Ophthalmol. Vis. Sci. 2008;49(13):277. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine if the Central Corneal Thickness (CCT) changes with IOP spikes following intravitreal injections.

Methods: : 22 intravitreal injections were administered in patients with exudative AMD. All patients received an average of 1 prophylactic IOP lowering medications one hour prior to the intravitreal injection. Central corneal thickness measured by corneal pachymetry and IOP measured by Tonopen-2 were both taken before and 1" after intravitreal injections. All eyes were lubricated with sterile BSS post-injection to keep the cornea hydrated.

Results: : The Mean Pre injection IOP was 13 ± 4 mm Hg. The mean IOP at 3-10" post-injection was 27 ± 7 mmHg. Mean CCT pre injection was 542 µm and post injection was 510 µm (p-value = 0.13). There was no statistically significant difference in the mean CCT before and after injections in this pilot study, though a trend was established. Differences were noted that might be statistically significant with a larger sample size.

Conclusions: : CCT measurements decreased with increasing IOP but not in a statistically significant fashion in this small study cohort.

Keywords: cornea: clinical science • age-related macular degeneration 
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