Abstract
Purpose: :
To determine if the Central Corneal Thickness (CCT) changes with IOP spikes following intravitreal injections.
Methods: :
22 intravitreal injections were administered in patients with exudative AMD. All patients received an average of 1 prophylactic IOP lowering medications one hour prior to the intravitreal injection. Central corneal thickness measured by corneal pachymetry and IOP measured by Tonopen-2 were both taken before and 1" after intravitreal injections. All eyes were lubricated with sterile BSS post-injection to keep the cornea hydrated.
Results: :
The Mean Pre injection IOP was 13 ± 4 mm Hg. The mean IOP at 3-10" post-injection was 27 ± 7 mmHg. Mean CCT pre injection was 542 µm and post injection was 510 µm (p-value = 0.13). There was no statistically significant difference in the mean CCT before and after injections in this pilot study, though a trend was established. Differences were noted that might be statistically significant with a larger sample size.
Conclusions: :
CCT measurements decreased with increasing IOP but not in a statistically significant fashion in this small study cohort.
Keywords: cornea: clinical science • age-related macular degeneration