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W. Nam, H. K. Seong, S. H. Bae, H. K. Kim; Preferential Hyperacuity Perimeter for Monitoring Choroidal Neovascularization After Intravitreal Injection of Bevacizumab. Invest. Ophthalmol. Vis. Sci. 2008;49(13):297.
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To assess the ability of the Preferential Hyperacuity Perimeter(PreView PHP) to evaluate the change of choroidal neovascularization(CNV) after intravitreal bevacizumab injection.
Ten patients with previously untreated choroidal neovascularization was followed after 1.25mg intravitreal bevacizumab injection. Primary disease entities included age related macular degeneration in 4 patients, polypoidal choroidal vasculopathy in 3 patients and retinal angiomatous proliferation in 3 patients. Ophthalmic evaluations including best-corrected ETDRS visual acuity, fluorescein angiography, pigment epithelial detachment(PED) height and PHP were performed at baseline and follow up visit. PED height was evaluated in the area patients show metamorphosias by means of the PHP
1 month after first intravitreal bevacizumab injection visual acuity improved in 5 patients(50%) and remained stable in 5 patients(50%). There was improvement of PHP in 5 patients(50%) and stabilization in 5 patients(50%). But the correlation between PHP and visual acuity was low.(p=0.499) 1 month after first bevacizumab injection the mean reductions of PED height were 101.2 microm in patients who had improvement of PHP and 15.7 microm who had stabilization of PHP. The changes of PHP were correlated with changes of PED height.(Spearman's correlation coefficient r = - 0.732 p = 0.039) Re-injections of bevacizumab according to standard criteria were performed in 4 patients.
The PHP was not useful in detecting the changes of visual acuity after intravitreal bevacizumab injection. But the PHP could represent the changes of PED height. This high correlation of PHP and PED height assessed by OCT demonstrates that PHP have significant ability in detecting the structural changes after bevacizumab injection rather than functional changes.
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