May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Visual and Anatomic Outcomes of Serous Pigment Epithelial Detachments Treated With Ranibizumab
Author Affiliations & Notes
  • J. S. Yankelove
    Ophthalmology, Vitreoretinal Consultants, Houston, Texas
  • M. S. Benz
    Ophthalmology, Vitreoretinal Consultants, Houston, Texas
  • D. M. Brown
    Ophthalmology, Vitreoretinal Consultants, Houston, Texas
  • R. Y. Kim
    Ophthalmology, Vitreoretinal Consultants, Houston, Texas
  • R. H. Fish
    Ophthalmology, Vitreoretinal Consultants, Houston, Texas
  • T. P. Wong
    Ophthalmology, Vitreoretinal Consultants, Houston, Texas
  • Footnotes
    Commercial Relationships  J.S. Yankelove, None; M.S. Benz, Genentech, C; Regeneron, C; Allergan, C; Alcon, C; D.M. Brown, Genentech, C; Regeneron, C; Allergan, C; Alcon, C; R.Y. Kim, None; R.H. Fish, None; T.P. Wong, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 332. doi:https://doi.org/
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      J. S. Yankelove, M. S. Benz, D. M. Brown, R. Y. Kim, R. H. Fish, T. P. Wong; Visual and Anatomic Outcomes of Serous Pigment Epithelial Detachments Treated With Ranibizumab. Invest. Ophthalmol. Vis. Sci. 2008;49(13):332. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate visual and anatomic outcomes in patients with serous pigment epithelial detachments treated with ranibizumab.

Methods: : Retrospective review of medical records and diagnostic images.

Results: : Of 231 eyes newly diagnosed with exudative age-related macular degeneration (AMD) in a six month time period, 29 (12.5%) were found to have a serous detachment of the retinal pigment epithelium (RPE). Of these 29 eyes, 24 completed six months of treatment and 3 of 24 (12.5%) developed a tear of the RPE during the first six months of treatment. Among the patients with serous detachment of the RPE treated with ranibizumab, mean visual acuity improved from 20/100 at baseline to 20/57 at the six-month time point.

Conclusions: : Patients with serous detachment of the RPE represent a distinct subgroup of patients with exudative AMD. Although these patients have a risk of tear of the RPE and attendant limitation in vision when treated with ranibizumab, patients treated with ranibizumab had a mean improvement in vision at the six-month time point.

Keywords: age-related macular degeneration • retinal pigment epithelium • clinical (human) or epidemiologic studies: outcomes/complications 
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