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Y. Ouyang, Y. Zhang, Y. Bi, J. Qian, J. Xu, G. Xu, Y. Yuan, Q. Chang; Clinical and Pathological Characteristics of the Ciliary Body Tumors in Chinese Patients of Han Nationality. Invest. Ophthalmol. Vis. Sci. 2008;49(13):34.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the clinical and pathological characteristics of the ciliary body tumors in Chinese patients of Han nationality.
Medical records and histopathological findings of fourty-seven patients with ciliary body tumors from 1987 to 2007 diagnosed in EENT hospital in Shanghai were studied retrospectively.
A total of 47 eyes from 47 cases were summarized. The mean age of the 47 cases was 39.13+/-19.21 years. Thirty-two patients were female (68.1%), fifteen were male (31.9%). The clinical presentation was visual acuity decrease (41 eyes in 47 cases),ocular redness (7 eyes),ocular pain(14 eyes),photophobia and tearing (5 eyes), dark spot (3 eyes),visual field damage (4 eyes),exotropia(1 eye) and exophthalmos(1 eye). The histological examination revealed malignant melanoma in 24 cases(51.1%),melanocytoma in 8 cases(17.0%), medulloepithelioma in 4 cases(8.5%),leiomyoma in 2 cases(4.3%),nerilemoma in 1 case(2.1%), pigment epithelium adenoma in 2 cases(4.3%),non-pigment epithelium adenoma in 1 patient(2.1%),non-special granuloma in 2 cases(4.3%),metastatic tumor in 1 case.One biopsy could not be differentiated between melanocytoma and ciliary epithelium adenoma.The mean age of malignant melanoma was 41.08+/-15.28 years.The ratio of female to male was 5 to 3. The melanocytoma was divided into benign(5 cases)and malignant(3 cases).The mean age of the benign group was 23+/-12.39 years,the malignant group 67.67+/-11.93 years.The mean age of medulloepithelioma was 16.75+/-17.52 years with a 3:1 female to male ratio.Patients with leiomyoma and non-special granuloma were all female.Some cases were misdiagnosed and operated improperly as primary glaucoma(3 eyes, antiglaucoma surgery),age-related cataract(1 eye,phacomusification and IOL implantation), cyclitis(2 eyes),vitreous floaters(1 eye),retinal detachment(1 eye,vitreous surgery) and ophthalmitis(vitreous and antiglaucoma surgery).A total rate of misdiagnosis was21.2%.
Patients with tumors of ciliary body have non-specific ocular complaints that may prevent consideration of a right diagnosis.With the application of UBM, ciliary body tumors can be detected in the early phase and the rate of misdiagnosis reduced sharply.However,ciliary body tumors may be difficult to differentiate before surgery.Malignant melanomas was the most common tumor of ciliary body followed by melanocytoma in China.A female preference may be found.With the increase of age,benign melanocytoma may become malignant which suggested the importance of close follow-up.
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