May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Anti VEGF Treatment of Classic Choroidal Newvessels in Age Related Macular Degeneration
Author Affiliations & Notes
  • C. M. Favard
    Ophthalmology, Rothschild Foundation, Paris, France
  • M. M. Mauget-Faÿsse
    Ophthalmology, Centre Rabelais, Lyon, France
  • C. C. Français
    Ophthalmology, Centre Ophtalmologique des Quinze-Vingt, Paris, France
  • G. G. Coscas
    Ophthalmology, Centre Ophtalmologique de l'Odéon, Paris, France
  • Footnotes
    Commercial Relationships  C.M. Favard, None; M.M. Mauget-Faÿsse, None; C.C. Français, None; G.G. Coscas, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 344. doi:https://doi.org/
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      C. M. Favard, M. M. Mauget-Faÿsse, C. C. Français, G. G. Coscas; Anti VEGF Treatment of Classic Choroidal Newvessels in Age Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):344. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Is visual prognosis of the rare classic choroidal newvessels (CNV) improved by intravitreal (IVT) antiVEGF treatment ?

Methods: : In this one year prospective study, we have analysed ETDRS visual acuity (VA), fluorescein angiography and OCT of classic CNVs, before and 4 to 6 weeks after each ranibizumab (6 eyes) or bevacizumab (6 eyes) IVT repeated after 2 initial sessions in case of persistence or recurrence.

Results: : Mean initial VA was 0,26 and final VA 0,20. Classic CNVs appeared occluded after first anti VEGF IVT in 3 eyes, after the second injection in 7 eyes and after third injection in 2 eyes. CNV recurrence occurred in 75% of cases after a mean evolution of 4 months. CNV scar appeared rapidly hyperpigmented in all cases with overlying retinal thinning on OCT and decreased vision of one or more ETDRS lines and central scotoma in 5 eyes. VA was increased in 5 eyes and stable in 2 eyes. In 2 cases a pseudomacular hole progressed to full thickness atrophic hole with a 1 and 4 lines VA decrease.

Conclusions: : Anti VEGFs therefore improve visual prognosis of classic CNVs but an hyperpigmented scar and retraction of pseudomacular hole can induce VA decrease.

Keywords: age-related macular degeneration • choroid: neovascularization • vascular endothelial growth factor 
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