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K. Miura, T. Sunada, Y. Nakahata, M. Nakatani, C. Taki, S. Nishimura; Investigation of the Poly(vinylpyrrolidone) Hydrogel as a Material for Accommodative Intraocular Lens. Invest. Ophthalmol. Vis. Sci. 2008;49(13):407.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate Poly(vinylpyrrolidone) (PVP) hydrogel in rabbit eyes for its safety and potential as a material for accommodative intraocular lens (IOL).
PVP hydrogel was implanted in the capsular bag of Japanese White rabbits. Slitlamp and fundus examinations were performed once a month for 11 months postoperatively. The anterior chamber depth (ACD) and the thickness of the PVP material were measured with a Scheimpflug camera to evaluate changes in the PVP thickness in the direction of the optic axis before and after general anesthesia with intramuscular Ketamine/Xylazine mixture. The eyes were enucleated and observed from the posterior capsule side with a stereoscopic microscope at 3 and 11 months postoperatively. Resin-embedded sections of the anterior segments were prepared for X-ray analysis to determine elements present in the posterior capsule.
Slitlamp examination revealed no inflammatory reaction or corneal opacification. The PVP hydrogel remained in place stably in the capsule bag for 11 months postoperatively. Posterior capsule opacification gradually increased, making the fundus invisible from 3 months postoperatively. The cells that proliferated into the posterior capsule, however, then became transparent, visualizing the optic nerve and retina through the PVP hydrogel at 6 months and later. Stereoscopic observation revealed clouded cell layers present between the PVP hydrogel and posterior capsule at 3 months, but clear thick cell layers at 11 months. In the Scheimpflug camera examination before and after general anesthesia, the ACD increased by 60-260 µm while the PVP thickness decreased by 50-400 µm in the direction of the optical axis. The X-ray analysis confirmed that no calcium by-products were present in the posterior capsule.
These results suggest that the PVP hydrogel is useful as a material for accommodative IOLs. Further study is necessary to elucidate morphological changes of the cells that proliferate into the posterior capsule, and to develop a technique to increase accommodative amplitudes.
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