May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
In vivo Micro-MRI to Assess the Anterior Segment in Rabbit Eyes After Experimental Lens Based Refractive Surgery
Author Affiliations & Notes
  • O. Stachs
    University of Rostock, Rostock, Germany
    Eye Hospital,
  • T. Terwee
    Eye Hospital, AMO BV, Groningen, The Netherlands
  • H. Martin
    University of Rostock, Rostock, Germany
    IBMT,
  • K. Schmitz
    University of Rostock, Rostock, Germany
    Eye Hospital,
  • S. Langner
    Radiology Department, University of Greifswald, Greifswald, Germany
  • N. Hosten
    Radiology Department, University of Greifswald, Greifswald, Germany
  • R. Guthoff
    University of Rostock, Rostock, Germany
    Eye Hospital,
  • Footnotes
    Commercial Relationships  O. Stachs, None; T. Terwee, AMO BV, E; H. Martin, None; K. Schmitz, AMO, F; S. Langner, None; N. Hosten, None; R. Guthoff, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 409. doi:https://doi.org/
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      O. Stachs, T. Terwee, H. Martin, K. Schmitz, S. Langner, N. Hosten, R. Guthoff; In vivo Micro-MRI to Assess the Anterior Segment in Rabbit Eyes After Experimental Lens Based Refractive Surgery. Invest. Ophthalmol. Vis. Sci. 2008;49(13):409. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Understanding and evaluating the biomechanical behaviour of artificial intraocular lenses presents a significant challenge, the solution of which may lie in high resolution anterior-segment imaging. The aim of the study is to use this technology to assess the anterior segment in rabbits after IOL surgery (monofocal IOL implantation, lens refilling).

Methods: : High-resolution magnetic resonance ocular images were acquired (7.1 Tesla, ClinScan, Bruker Bioscan) using a rat brain coil and a standard spin-echo radio-frequency pulse sequence in rabbits after lens-based refractive surgery in combination with an intra-operative antiproliferative treatment to prevent LEC proliferation. Single slices and 3D reconstructions were used to assess the anterior eye segment up to 3 years postop.

Results: : IOL placement (tilting, centration) and the retroiridian haptic configuration were evaluated in 3 dimensions. Lens capsule and implant were in close contact 1 year after implantation, whereas the capsular bag had experienced retroiridial expansion in a case of extensive excentric Soemmering's ring formation. The spatial arrangement (radius of curvature, axial and equatorial diameters) of refilled lenses was visualized by in vivo micro-MRI. In partially filled eyes, the capsular bag and silicon polymer were separated; however, in completely refilled eyes, the capsule and homogenous silicone polymer came in close contact with no visible interface. A different radius of curvature was found especially in the equatorial region between the refilled lens (3 years postop) compared to the crystalline lens of the contralateral eye (see figure).

Keywords: anterior segment • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • accomodation 
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