May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Cyber-Knife Radiosurgery: A New Treatment Method for Image-Guided and Robot-Assisted Precision Radiation of Uveal Melanomas
Author Affiliations & Notes
  • U. C. Schaller
    Dept Ophthalmology, University of Munich LMU, Munich, Germany
  • A. Muacevic
    European Cyberknife Center Munich, Munich, Germany
  • M. Nentwich
    Dept Ophthalmology, University of Munich LMU, Munich, Germany
  • I. Reiniger
    Dept Ophthalmology, University of Munich LMU, Munich, Germany
  • P. Foerster
    Dept Ophthalmology, University of Munich LMU, Munich, Germany
  • B. Wowra
    European Cyberknife Center Munich, Munich, Germany
  • A. Kampik
    Dept Ophthalmology, University of Munich LMU, Munich, Germany
  • Footnotes
    Commercial Relationships  U.C. Schaller, None; A. Muacevic, E, E; M. Nentwich, None; I. Reiniger, None; P. Foerster, None; B. Wowra, E, E; A. Kampik, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 41. doi:https://doi.org/
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      U. C. Schaller, A. Muacevic, M. Nentwich, I. Reiniger, P. Foerster, B. Wowra, A. Kampik; Cyber-Knife Radiosurgery: A New Treatment Method for Image-Guided and Robot-Assisted Precision Radiation of Uveal Melanomas. Invest. Ophthalmol. Vis. Sci. 2008;49(13):41. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : We report our first experience with a image-guided and robot assisted precision radiosurgery using the Cyber-knife in uveal melanomas unsuitable for brachytherapy (Ru-106).

Methods: : So far 19 Patients were treated in a single-session computed tomography-guided radiosurgery . In 7 of these Patients we have a follow up of min. 6 months (5 male, 2 female; age median: 61 years (95% Confidence Interval (CI): 60-70 years); 4 right eyes, 3 left eyes).The localisation and size of the tumors did not allow for brachytherapy (Ru-106). All patients underwent regular clinical, echographical and neuroradiological follow-up examinations.

Results: : The follow-up time was median 11 months. A local tumor control defined as either continuous tumor regression or stopping of tumor progression was achieved in all patients within observation period. In one patient a transscleral tumor resection was perfomed after radiotherapy. Maximum apical tumor hight according to standardized A-scan before treatment was median 7.0 mm (25% quartile: 6.25 mm, 75% quartile: 9.8 mm) and after treatment median 5.0 mm (25% quartile: 3.95 mm, 75% quartile 7.1 mm).

Conclusions: : Our preliminary results indicate that the frameless real-time image-guided radiosurgery using the Cyber-knife is beneficial in retaining the eyes of patients with uveal melanomas that are not suitable for brachytherapy (Ru-106).

Keywords: melanoma • radiation therapy • tumors 
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