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U. C. Schaller, A. Muacevic, M. Nentwich, I. Reiniger, P. Foerster, B. Wowra, A. Kampik; Cyber-Knife Radiosurgery: A New Treatment Method for Image-Guided and Robot-Assisted Precision Radiation of Uveal Melanomas. Invest. Ophthalmol. Vis. Sci. 2008;49(13):41. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
We report our first experience with a image-guided and robot assisted precision radiosurgery using the Cyber-knife in uveal melanomas unsuitable for brachytherapy (Ru-106).
So far 19 Patients were treated in a single-session computed tomography-guided radiosurgery . In 7 of these Patients we have a follow up of min. 6 months (5 male, 2 female; age median: 61 years (95% Confidence Interval (CI): 60-70 years); 4 right eyes, 3 left eyes).The localisation and size of the tumors did not allow for brachytherapy (Ru-106). All patients underwent regular clinical, echographical and neuroradiological follow-up examinations.
The follow-up time was median 11 months. A local tumor control defined as either continuous tumor regression or stopping of tumor progression was achieved in all patients within observation period. In one patient a transscleral tumor resection was perfomed after radiotherapy. Maximum apical tumor hight according to standardized A-scan before treatment was median 7.0 mm (25% quartile: 6.25 mm, 75% quartile: 9.8 mm) and after treatment median 5.0 mm (25% quartile: 3.95 mm, 75% quartile 7.1 mm).
Our preliminary results indicate that the frameless real-time image-guided radiosurgery using the Cyber-knife is beneficial in retaining the eyes of patients with uveal melanomas that are not suitable for brachytherapy (Ru-106).
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