A Comparison of the Antimicrobial Activity of Hydrophobic Acrylic versus Hydrophilic Collamer Intraocular Lenses Soaked in Moxifloxacin 0.5% for One Hour

Abstract

Purpose: : To compare the antimicrobial activity of Alcon Acrysof SN60 acrylic hydrophobic intraocular lenses to the STARR Afinity CQ2015 Collamer hydrophilic intraocular lens after soaking in moxifloxacin 0.5% for one hour.

Methods: : Twenty (20) STARR Afinity CQ2015 Collamer intraocular lenses and twenty (20) Alcon Acrysof SN60 acrylic intraocular lenses were soaked in moxifloxacin 0.5% for one hour, then air dried for one minute on each side and plated on Mueller Hinton agar with quality controlled ATCC 25923 Staphylococcus aureus overlay.

Results: : All antibiotic soaked IOLs had kill zones. Average kill zones for the STARR Afinity hydrophilic collamer lens (40.2mm) was greater than for the Alcon SN60 hydrophobic acrylic lens (36.5mm). A comparison of condition means was performed using repeated measure ANOVA which was found to be highly significant P<0.001.

Conclusions: : Both acrylic and collamer antibiotic soaked lenses have antimicrobial activity. Hydrophilic collamer lenses have greater antimicrobial activity than hydrophobic acrylic IOLs after soaking in moxifloxacin 0.5% for one hour.

Keywords: intraocular lens • antibiotics/antifungals/antiparasitics • clinical laboratory testing