May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Vitreous Hemorrhage After Plaque Radiotherapy for Uveal Melanoma
Author Affiliations & Notes
  • C. G. Bianciotto
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • C. Pirondini
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • C. L. Shields
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • M. Furuta
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • A. Mashayekhi
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • J. A. Shields
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  C.G. Bianciotto, None; C. Pirondini, None; C.L. Shields, None; M. Furuta, None; A. Mashayekhi, None; J.A. Shields, None.
  • Footnotes
    Support  Support provided by the Retina Research Foundation of the Retina Society in Cape Town, South Africa (CLS); the Paul Kayser International Award of Merit in Retina Research, Houston TX (JAS); a donation
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 47. doi:https://doi.org/
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    • Get Citation

      C. G. Bianciotto, C. Pirondini, C. L. Shields, M. Furuta, A. Mashayekhi, J. A. Shields; Vitreous Hemorrhage After Plaque Radiotherapy for Uveal Melanoma. Invest. Ophthalmol. Vis. Sci. 2008;49(13):47. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the incidence, etiology and management of late-onset vitreous hemorrhage after plaque radiotherapy for uveal melanoma.

Methods: : Retrospective study

Results: : Of 3813 eyes treated with plaque radiotherapy for uveal melanoma, 403 (11%) developed late-onset vitreous hemorrhage. The prevalence of diabetes and hypertension in these patients was 15% and 35%, respectively. Presumed causes of hemorrhage included proliferative radiation retinopathy (28%), tumor necrosis (21%), posterior vitreous detachment (15%),retinal invasion (10%), and unknown (18%). The mean interval between plaque radiotherapy and vitreous hemorrhage was 26 months. The tumors were mushroom shaped in 40% and showed retinal invasion in 18%. The most common forms of management included observation in 48%, laser photocoagulation in 24%, and vitrectomy in 18%. After a mean follow up period of 5 years, the rate of tumor recurrence was 7%; metastasis 9%, and enucleation 15%. In the subset of patients who underwent vitrectomy, these rates were not increased (3%, 5% and 9% respectively).

Conclusions: : The overall incidence of late-onset vitreous hemorrhage after plaque radiotherapy for uveal melanoma was 11%. Proliferative radiation retinopathy, tumor necrosis and posterior vitreous detachment were the most common etiologies. Tumor recurrence at 5 years was 7%.

Keywords: melanoma • radiation therapy • vitreous 
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