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N. Horgan, C. L. Shields, A. Mashayekhi, M. A. Materin, P. F. Salazar, M. O'Regan, J. A. Shields; Macular Edema Following Plaque Radiotherapy of Uveal Melanoma: A Proposed OCT-Based Grading System. Invest. Ophthalmol. Vis. Sci. 2008;49(13):48.
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To assess the relaibility and validity of an optical coherence tomography (OCT) based grading scale for macular edema following plaque radiotherapy of uveal melanoma.
An inter-rater reliability study of a proposed five point grading scale was conducted. Assessment of the correlation between the grading scale, foveal thickness and visual acuity measurements in 139 eligible patients with a diagnosis of radiation-induced macular oedema was then undertaken.
The grading scale was highly reliable (kappa=0.91, z = 32.96, p=0.000). The grading scale also correlated with foveal thickness (Spearman’s correlation coefficient [rho] =0.56, p<0.0001) and visual acuity (rho =0.39, p<0.0001).
This pilot study suggests that OCT-based methods are feasible in the grading of macular edema following plaque radiatiotherapy of uveal melanoma.
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