May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Macular Edema Following Plaque Radiotherapy of Uveal Melanoma: A Proposed OCT-Based Grading System
N. Horgan; C. L. Shields; A. Mashayekhi; M. A. Materin; P. F. Salazar; M. O'Regan; J. A. Shields
Author Affiliations & Notes
  • N. Horgan
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • C. L. Shields
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • A. Mashayekhi
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • M. A. Materin
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • P. F. Salazar
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • M. O'Regan
    Department of Statistics, Trinity College, Dublin, Ireland
  • J. A. Shields
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  N. Horgan, None; C.L. Shields, None; A. Mashayekhi, None; M.A. Materin, None; P.F. Salazar, None; M. O'Regan, None; J.A. Shields, None.
  • Footnotes
    Support  Irish College of Ophthalmologists/Pfizer Fellowship 2005, Royal College of Surgeons in Ireland Travelling Fellowship 2005
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 48. doi:
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      N. Horgan, C. L. Shields, A. Mashayekhi, M. A. Materin, P. F. Salazar, M. O'Regan, J. A. Shields; Macular Edema Following Plaque Radiotherapy of Uveal Melanoma: A Proposed OCT-Based Grading System. Invest. Ophthalmol. Vis. Sci. 2008;49(13):48.

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Abstract

Purpose: : To assess the relaibility and validity of an optical coherence tomography (OCT) based grading scale for macular edema following plaque radiotherapy of uveal melanoma.

Methods: : An inter-rater reliability study of a proposed five point grading scale was conducted. Assessment of the correlation between the grading scale, foveal thickness and visual acuity measurements in 139 eligible patients with a diagnosis of radiation-induced macular oedema was then undertaken.

Results: : The grading scale was highly reliable (kappa=0.91, z = 32.96, p=0.000). The grading scale also correlated with foveal thickness (Spearman’s correlation coefficient [rho] =0.56, p<0.0001) and visual acuity (rho =0.39, p<0.0001).

Conclusions: : This pilot study suggests that OCT-based methods are feasible in the grading of macular edema following plaque radiatiotherapy of uveal melanoma.

Keywords: melanoma • macula/fovea • imaging/image analysis: clinical 
© 2008, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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