May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Macular Edema Following Plaque Radiotherapy of Uveal Melanoma: A Proposed OCT-Based Grading System
Author Affiliations & Notes
  • N. Horgan
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • C. L. Shields
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • A. Mashayekhi
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • M. A. Materin
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • P. F. Salazar
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • M. O'Regan
    Department of Statistics, Trinity College, Dublin, Ireland
  • J. A. Shields
    Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  N. Horgan, None; C.L. Shields, None; A. Mashayekhi, None; M.A. Materin, None; P.F. Salazar, None; M. O'Regan, None; J.A. Shields, None.
  • Footnotes
    Support  Irish College of Ophthalmologists/Pfizer Fellowship 2005, Royal College of Surgeons in Ireland Travelling Fellowship 2005
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 48. doi:https://doi.org/
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      N. Horgan, C. L. Shields, A. Mashayekhi, M. A. Materin, P. F. Salazar, M. O'Regan, J. A. Shields; Macular Edema Following Plaque Radiotherapy of Uveal Melanoma: A Proposed OCT-Based Grading System. Invest. Ophthalmol. Vis. Sci. 2008;49(13):48. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the relaibility and validity of an optical coherence tomography (OCT) based grading scale for macular edema following plaque radiotherapy of uveal melanoma.

Methods: : An inter-rater reliability study of a proposed five point grading scale was conducted. Assessment of the correlation between the grading scale, foveal thickness and visual acuity measurements in 139 eligible patients with a diagnosis of radiation-induced macular oedema was then undertaken.

Results: : The grading scale was highly reliable (kappa=0.91, z = 32.96, p=0.000). The grading scale also correlated with foveal thickness (Spearman’s correlation coefficient [rho] =0.56, p<0.0001) and visual acuity (rho =0.39, p<0.0001).

Conclusions: : This pilot study suggests that OCT-based methods are feasible in the grading of macular edema following plaque radiatiotherapy of uveal melanoma.

Keywords: melanoma • macula/fovea • imaging/image analysis: clinical 
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