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D. S. Rudich, C. L. Shields, C. Bianciotto, A. Mashayekhi, M. Materin, A. Ganguly, J. A. Shields; Chromosome 3 Analysis of Small Choroidal Melanoma: Correlation With Clinical Features in 108 Cases. Invest. Ophthalmol. Vis. Sci. 2008;49(13):51.
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To evaluate the relationship between patient and tumor characteristics and chromosome 3 status in small choroidal melanoma.
Retrospective review of the clinical records of patients with small choroidal melanoma who underwent fine-needle aspiration biopsy (FNAB) for genetic testing for chromosome 3 status between November 2005 and August 2007 on the Oncology Service at Wills Eye Institute. FNAB was performed immediately before plaque radiotherapy via pars plana transvitreal approach using a 27-gauge long needle. Genetic analysis was done using DNA amplification and microsatellite assay and the patients were divided into monosomy 3, disomy 3, and inconclusive data groups.
Of 108 patients, 32 (30%) had monosomy 3, 59 (55%) demonstrated disomy 3, and 17 (15%) had insufficient/inconclusive DNA samples. The median patient age in both the monosomy 3 and disomy 3 groups was 58 years. 65% of patients in the monosomy 3 group had blue/green iris vs. 66% in the disomy group. With respect to tumor characteristics, monosomy 3 patients demonstrated the following (as compared to disomy 3 patients): thickness over 2 millimeters in 75% (vs. 78%), subretinal fluid in 88% (vs. 86%), symptoms in 38% (vs. 53%), orange pigment in 69% (vs. 78%), location within 3 millimeters to the optic disc margin in 50% (vs. 53%), drusen in 22% (vs. 24%), acoustic hollowness on B-scan ultrasonography in 91% (vs. 88%), and documented growth in 66% (vs. 46%).
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