May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Chromosome 3 Analysis of Small Choroidal Melanoma: Correlation With Clinical Features in 108 Cases
Author Affiliations & Notes
  • D. S. Rudich
    Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania
  • C. L. Shields
    Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania
  • C. Bianciotto
    Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania
  • A. Mashayekhi
    Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania
  • M. Materin
    Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania
  • A. Ganguly
    Department of Genetics, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
  • J. A. Shields
    Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  D.S. Rudich, None; C.L. Shields, None; C. Bianciotto, None; A. Mashayekhi, None; M. Materin, None; A. Ganguly, None; J.A. Shields, None.
  • Footnotes
    Support  The Eye Tumor Research Foundation, Philadelphia, PA
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 51. doi:https://doi.org/
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      D. S. Rudich, C. L. Shields, C. Bianciotto, A. Mashayekhi, M. Materin, A. Ganguly, J. A. Shields; Chromosome 3 Analysis of Small Choroidal Melanoma: Correlation With Clinical Features in 108 Cases. Invest. Ophthalmol. Vis. Sci. 2008;49(13):51. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the relationship between patient and tumor characteristics and chromosome 3 status in small choroidal melanoma.

Methods: : Retrospective review of the clinical records of patients with small choroidal melanoma who underwent fine-needle aspiration biopsy (FNAB) for genetic testing for chromosome 3 status between November 2005 and August 2007 on the Oncology Service at Wills Eye Institute. FNAB was performed immediately before plaque radiotherapy via pars plana transvitreal approach using a 27-gauge long needle. Genetic analysis was done using DNA amplification and microsatellite assay and the patients were divided into monosomy 3, disomy 3, and inconclusive data groups.

Results: : Of 108 patients, 32 (30%) had monosomy 3, 59 (55%) demonstrated disomy 3, and 17 (15%) had insufficient/inconclusive DNA samples. The median patient age in both the monosomy 3 and disomy 3 groups was 58 years. 65% of patients in the monosomy 3 group had blue/green iris vs. 66% in the disomy group. With respect to tumor characteristics, monosomy 3 patients demonstrated the following (as compared to disomy 3 patients): thickness over 2 millimeters in 75% (vs. 78%), subretinal fluid in 88% (vs. 86%), symptoms in 38% (vs. 53%), orange pigment in 69% (vs. 78%), location within 3 millimeters to the optic disc margin in 50% (vs. 53%), drusen in 22% (vs. 24%), acoustic hollowness on B-scan ultrasonography in 91% (vs. 88%), and documented growth in 66% (vs. 46%).

Keywords: choroid • melanoma • genetics 
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