May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
The Pathogen and Antifugal Susceptibility of Fungal Keratitis in 2003~2007 of Middle China
Author Affiliations & Notes
  • Q. Zeng
    Corneal diseases, Wuhan Aier Eye Hospital, Wuhan, China
  • X. Niu
    Corneal diseases, Wuhan Aier Eye Hospital, Wuhan, China
  • F. Wu
    Corneal diseases, Wuhan Aier Eye Hospital, Wuhan, China
  • Footnotes
    Commercial Relationships  Q. Zeng, None; X. Niu, None; F. Wu, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 510. doi:
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      Q. Zeng, X. Niu, F. Wu; The Pathogen and Antifugal Susceptibility of Fungal Keratitis in 2003~2007 of Middle China. Invest. Ophthalmol. Vis. Sci. 2008;49(13):510.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To study the pathogenic characteristics and antifungalsusceptibility of fungal keratitis during 2003~2007 in Hubei area, Middle China.

 
Methods:
 

From August 2003 to July 2007, 289 samples from cornea were taken for fungal culture. Positive samples were analyzed for classification and isolate frequency. Two antifungal susceptibility test in vitro, ATB FUNGUS 2 test(bioMérieux Corp., France) and E-test(AB BIODISK, Sweden), were used to evaluate susceptibility(MICs) of these fungal pathogens against amphotericin B, fluconazole, and itraconazole.

 
Results:
 

In 289 samples, 188 cultures appeared positive. Fusarium species is the most frequent corneal fungal pathogen(66%), followed by Aspergillus species(8.5%). Dematiacious fungi including Alternaria species, Curvularia species are also common pathogens(13.8%). The sensitivity of Fusarium species to amphotericin B, itraconazole, and fluconazole is 71.0%, 29.0% and 16.1%; the sensitivity of Aspergillus species to amphotericin B, itraconazole, and fluconazole is 25%,75%,25%; the sensitivity of Dematiacious fungi to amphotericin B, itraconazole, and fluconazole is 100%,85.7%,85.7%; the sensitivity of other unknown fungi to amphotericin B, itraconazole, and fluconazole is 75%,75%,100%.The coincidence rate of drug sensitivity of amphotericin B, itraconazole, and fluconazole tested by ATB FUNGUS 2 test and E-test is 95.8%, 93.8% and 87.5%(P>0.05).

 
Conclusions:
 

Fusarium species is the main corneal fungal pathogen. Dematiacious fungi such as Alternaria species become more common than ever. Amphotericin B has a high antifungal activity in vitro and may be used as first medication for fungal keratitis. ATB FUNGUS 2 test may be a routine antifungal susceptibility test for corneal fungal pathogens.  

 
Keywords: fungal disease • microbial pathogenesis: experimental studies • antibiotics/antifungals/antiparasitics 
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