May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Positive Dual-Modality PET/CT Imaging of Primary Choroidal Melanoma is Associated With Monosomy 3
Author Affiliations & Notes
  • S. Reddy
    Vitreoretinal service, Jules Stein Eye Institute, Los Angeles, California
  • M. Auerbach
    Vitreoretinal service, Jules Stein Eye Institute, Los Angeles, California
  • B. Burgess
    Vitreoretinal service, Jules Stein Eye Institute, Los Angeles, California
  • T. A. Young
    Vitreoretinal service, Jules Stein Eye Institute, Los Angeles, California
  • Footnotes
    Commercial Relationships  S. Reddy, None; M. Auerbach, None; B. Burgess, None; T.A. Young, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 53. doi:https://doi.org/
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    • Get Citation

      S. Reddy, M. Auerbach, B. Burgess, T. A. Young; Positive Dual-Modality PET/CT Imaging of Primary Choroidal Melanoma is Associated With Monosomy 3. Invest. Ophthalmol. Vis. Sci. 2008;49(13):53. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The metabolic activity of choroidal melanoma may be identified with dual-modality PET/CT imaging. Cytogenetic testing may help classify patients with choroidal melanoma into two categories based on chromosome 3 status of the primary tumor tissue: those with monosomy 3 or high risk for metastasis, and those without monosomy 3 or low risk for metastasis. This study correlated the cytogenetic result with respect to monosomy 3 in primary choroidal melanoma with the degree of metabolic tumor activity as identified by dual-modality PET/CT imaging.

Methods: : Patients with choroidal melanoma greater than or equal to 6 mm in greatest basal diameter with known choromosome 3 status and who underwent whole body dual-modality PET/CT imaging at UCLA were included. The cytogenetic test result with respect to monosomy 3 of the primary tumor and its metabolic activity, measured in standard uptake values (SUV) by dual-modality PET/CT imaging, were evaluated.

Results: : Twenty-five patients with choroidal melanoma were included. Ten (40%) of the 25 were monosomy 3 positive. Six (60%) of the 10 monosomy 3 tumors had positive metabolic activity identified by PET/CT imaging. There was a statistically significant association between metabolically active tumors detected by PET/CT and monosomy 3 (Fisher exact test p=0.001). Positive PET/CT imaging was 60% sensitive and 100% specific for the identification of monosomy 3 status of the primary tumor.

Keywords: melanoma • imaging/image analysis: clinical • gene microarray 
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