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S. Marchi, P. Ramolfo, E. Mantovani, E. Marziani, G. Staurenghi; Combined Use of Anecortave-PDT for the Treatment of Retinal Angiomatous Proliferation Stage 2-3 in Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):548.
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To report the results of retinal angiomatous proliferation (RAP) treatment using subtenon injection of Anecortave combined with PDT.
This is a prospective review of consecutive patients with age-related macular degeneration who underwent treatment of RAP from June 1, 2006, through June 1, 2008. Inclusion criteria were: no previous treatment and diagnosis of RAP at stage 2-3 based on dynamic indocyanine green angiography (ICGA) and fluorescein angiography (FA). Patients received a subtenon injection of Anecortave followed by PDT after 15 days. Follow-up visits were scheduled every months with visual acuity (ETDRS charts), FA and ICGA. Decision for retreatment was based upon worsening of leakage on angiography and/or decreased visual acuity. Retreatment protocol included a PDT every three months. All patients underwent a repeated injection of Anecortave after six months.
Ten patients (10 eyes) with stage 2 RAP (6 eyes) and with stage 3 RAP (4 eyes) were identified. Ten patients were followed for at least six months and 4 patients for 12 months.During injection of Anecortave blooding and reflux occurred in 3 patients each.At six months, a functional improvement (> = 2 lines) was achieved in 3 Patients: 2 at stage 2 and 1 stage 3. A steady state was recorded in 5 patients (3 at stage 2 and 2 at stage 3) and decreased vision (<= 2 lines) occurred in 2 patients: 1 at stage 2 and 1 at stage 3.Anatomically, all the lesions remained perfused after treatment.Only 4 patients were seen after 12 months of follow-up, so the results are still preliminary.
Six months results after combined treatment of Anecortave-PDT seem to be promising with 8 out of 10 patients showing a stable or improved functional outcome. We are waiting for results at 12 months of follow-up.
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