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J. C. Freire, A. Teixeira, A. L. Coutinho, R. Velletri, T. Mattos, P. P. Bonomo; Interpretation of the OCT in Pacients With Choroidal Neovascularization Due to Age-Related Macular Degeneration Treated With PDT Combined With Intravitreal Bevacizumab versus Intravitreal Bevacizumab Alone. Invest. Ophthalmol. Vis. Sci. 2008;49(13):557.
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To evaluate the area of hiperreflectivity on the OCT measuring it longitudinal diameter and thickness to compare the changes of the choroidal neovascularization (CNV) during the therapy with PDT combined with intravitreal bevacizumab versus intravitreal bevacizumab alone.
A prospective study of nine consectuve eyes presenting CNV secondary of AMD in at least 1 eye that had never been treated previously.They were randomly assigned to receive either a single PDT session with verteporfin combine with IVB and two consecutive monthly IVB injection (group G1), or three consecultive monthly administration of IVB 1.25 mg (group G2). Was performed OCT measuring the areas of hiperreflective with longitudinal sections (90° and 180°) and their thickness in microns, then compared the areas at the baseline, 1st ,7 st ,15 st,30, 60 and 90 days after the start of the therapy. The lesion was measured also using de ICG on the baseline and 90 days after the start of the therapy.
The study showed in the measures made with the OCT a reductions of The thickness of the hiperreflective area maintaining it extension during both group during treatment period. The ICG measureswas higher then the measures found with the OCT, with reduction during the treatment period.
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