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S.-Y. Yu, E.-S. Kim, J.-H. Park, H.-W. Kwak; The Changes in Metamorphopsia Following Photodynamic Therapy and Anti-VEGF Treatment in Patients With Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):567. doi: https://doi.org/.
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To evaluate the result of preferential hyperacuity perimeter (PHP, Foresee PHPTM, Carl Zeiss, Germany) following photodynamic therapy (PDT) and anti-VEGF treatment in patients with choroidal neovascularization (CNV) secondary to age-related macular degeneration (ARMD).
Ten eyes of 10 patients with CNV secondary to AMD were treated with PDT and/or anti-VEGF agent. Best-corrected visual acuity (BCVA), optical coherence tomography (OCT) and PHP were carried out at baseline and follow-up visits after treatment. We compared hyperacuity deviation map and P-value in PHP before and after treatment. Then we correlated changes in resullts of PHP with BCVA and macular thickness using OCT.
Out of 10 eyes, 2 eyes received PDT alone and the 8 eyes received PDT and anti-VEGF combination treatment. In all 5 eyes showed BCVA improvement and favorable macular change using OCT, the area of hyperacuity defect zone was decreased and moved away from fovea, and P-value in PHP result was increased. Those changes were definite with follow-up especially between 8 to 12 weeks after treatment. In 5 eyes showed no improvement in BCVA, the hyperacuity defect and P-value was improved in 1 eye, stable in 2 eyes, and detoreorated in 2 eyes. In 3 eyes, there was no consistency in improvements among PHP and BCVA/OCT, especially in early follow-up tests between 1 to 8 week.
Our results suggest that PHP may be beneficial for monitoring patients with CNV secondary to AMD following PDT and/or anti-VEGF treatment. These results require further validation in a larger population.
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