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M. Yamamoto, T. Kohno, K. Shiraki, N. Miki, Y. Nomura, M. Kaida, S. Ataka, M. Hirabayashi; Recurrent Polypoidal Choroidal Vasculopathy After Long-Term Follow-Up of Photodynamic Therapy With Verteporfin. Invest. Ophthalmol. Vis. Sci. 2008;49(13):570.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the recurrent cases of polypoidal choroidal vasculopathy (PCV) after photodynamic therapy (PDT) with verteporfin.
Forty-five eyes of forty-four consecutive patients with PCV, whose polyps had disappeared after the first PDT and who had completed at least one-year follow-up, were studied retrospectively. PDT retreatment was performed when polypoidal lesions recurred and leakage was seen on fluorescein (FA) and indocyanine green angiograms (IA). The recurrence rates and the recurrence regions were studied, and the mean logMAR best corrected visual acuity (BCVA) changes from baseline were compared between the recurrence and the non-recurrence group.
The mean follow-up period was 23.4 months. Polypoidal lesions recurred in 12 eyes of 45 eyes (26.7%) at one-year follow-up, 10 eyes of 30 eyes (33.3%) at two-year follow-up, 6 eyes of 9 eyes (66.7%) at 3 year follow-up. Throughout all the follow-up periods, polypoidal lesion recurred in 18 eyes (40.0%) in the average of 14.0 months. The recurrence regions were at the same sites as the pre-operative regions in 6 eyes, within the abnormal vascular networks in 5 eyes and around the abnormal vascular networks in 7 eyes. Mean log MAR BCVA changes showed an improvement of 1.4 and 2.6 lines in the recurrence group and the non-recurrence group, respectively (p=0.16, Mann-Whitney’s U-test).
PCV recurred at a high probability for the long-term follow-up even when polypoidal lesions disappeared completely after PDT. Continuing follow-up examinations and periodic FA and IA are recommended.
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