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L. Chen, R. Buggage, A. I. Barsdorf, A. M. Pleil, for the PERSPECTIVES Study Group; Validation of Internationalized Bailey-Lovie Near Vision Charts and Reading Speed Charts in Subjects With Neovascular Age-Related Macular Degeneration (NV-AMD). Invest. Ophthalmol. Vis. Sci. 2008;49(13):571. doi: https://doi.org/.
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To examine the validity of the Bailey-Lovie Near Vision Charts and Reading Speed Charts adapted for international use in a multi-country clinical trial assessing visual function in patients diagnosed with NV-AMD.
The Bailey-Lovie charts and reading speed charts were translated for use in multiple European languages including French, German, Spanish, Portuguese, Italian, Turkish, Greek, Flemish, Polish and Czech. The internationalized charts were used along with distance visual acuity (VA) and contrast sensitivity as a measure of visual function in subjects enrolled in the PERSPECTIVES study, a 102 week multi-center clinical trial for the treatment of NV-AMD. Near VA (logMAR score at 25 cm) and distance VA (EDTRS letters at 2 m) were measured at baseline, weeks 6, 12 and 30. Reading speed (words/minute at 25 cm) and Pelli-Robson contrast sensitivity (logMAR score at 1 m) were measured at baseline and week 30.
The visual function results of 113 subjects completing 30 weeks of study follow-up were analyzed. A significant correlation was found between near VA and distance VA at baseline (r=.79, p<.0001), week 6 (r=.88, p<.0001), week 12 (r=.90, p<.0001), and week 30 (r=.89, p<.0001), between near VA and reading speed at baseline (r=.58, p<.0001) and week 30 (r=.79, p<.0001), and between near VA and contrast sensitivity at baseline (r=.51, p<.0001) and week 30 (r=.49, p<.0001). A significant correlation was found between reading speed and distance VA at baseline (r=.49, p<.0001) and week 30 (r=.72, p<.0001), and between reading speed and contrast sensitivity at baseline (r=.36, p<.0002) and week 30 (r=.41, p<.0001).
In subjects with NV-AMD, the internationalized Bailey-Lovie scores for near VA and reading speed show significant correlations with standardized measures of distance VA and contrast sensitivity supporting the validity of the measures in the target languages tested.
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