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K. Fujita, R. Mori, M. Yuzawa; Fixation Status and Reading Performance Before and 1 Year After Photodynamic Therapy in Patients With Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):573. doi: https://doi.org/.
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To evaluate the relationship of the position and light sensitivity of the fixation area with reading performance before and 1 year after photodynamic therapy (PDT) in the patients with age-related macular degeneration (AMD).Patients and
Nineteen eyes with AMD were studied. Before and 1 year after PDT, corrected visual acuity was measured, the position of the fixation area and light sensitivity were determined using scanning laser ophthalmoscopic microperimetry, and reading acuity(RA), critical print size(CPS) and maximum reading speed(MRS)were determined using MNREAD-J.
After PDT, visual acuity was improved by 0.2 log units or more in 7 eyes, remained stable in 7 eyes, and worsened by 0.2 log units or more in 5 eyes. The position of fixation area was unchanged 14 eyes and was shifted in 4 eyes 1 year after PDT, one eye was undetermined fixation area before PDT. Light sensitivity in the fixation area was evaluated in 14 eyes, excluded 5 eyes that showed a shift in fixation area after PDT or undetermined before PDT. Light sensitivity was improved in 8 eyes, unchanged in 2 eyes, and worsened in 4 eyes. RA was improved in 4 eyes, unchanged in 8 eyes, and worsened in 7 eyes. CPS was improved in 5 eyes, unchanged in 4 eyes, and worsened in 10 eyes. MRS was worsened in 7 eyes.Unchanged fixation area as well as improved light sensitivity after PDT was associated with improved or unchanged reading performance, and shift fixation area toward peripheral visual field or worsened light sensitivity was associated with worsened reading performance.
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