May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Partial Recovery of Choroidal Blood Flow After Photodynamic Therapy
Author Affiliations & Notes
  • G. Watanabe
    Ophthalmology, Gunma Univ Sch of Med, Maebashi-Shi, Japan
  • S. Kishi
    Ophthalmology, Gunma Univ Sch of Med, Maebashi-Shi, Japan
  • Footnotes
    Commercial Relationships  G. Watanabe, None; S. Kishi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 579. doi:https://doi.org/
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      G. Watanabe, S. Kishi; Partial Recovery of Choroidal Blood Flow After Photodynamic Therapy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):579. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To observe the choroidal circulation after photodynamic therapy (PDT) using laser speckle flowgraphy (LSFG).

Methods: : We examined choroidal blood flow in 11 eyes of 11 patients (10 men and 1 woman) with exudative age-related macular degeneration using LSFG before PDT and at 1week, 3 months after PDT. The patients’ age ranged from 52 to 83 (mean, 66). Chorioretinal blood flow is expressed as a mean square burr rate (MBR) in LSFG. The examined areas were targeted to A which was located within the greatest linear dimension (GLD) of PDT but excluded from the lesion and to B which was located outer to the GLD. The MBR of the B served for control. Choroidal blood flow of the irradiated area (A) was assessed as the ratio to that of the control area (B).

Results: : After PDT, the MBR of the A decreased compared with that of the control area (B). Before PDT, A/B ratio was 0.8-2.07 (average 1.19), while it decreased to 0.41-1.14(0.84) at 1 week after PDT but recovered to 0.57-1.43 (average 0.92) at 3months. When preoperative mean A/B ratio is determined to 100%, postoperative choroidal blood flow was 71% at 1 week and 78% at 3 months.

Conclusions: : The choroidal blood flow was maximally decreased at one week after PDT but gradually recovered during postoperative 3 months. However the blood flow remained at 78% of preoperative level.

Keywords: age-related macular degeneration • choroid: neovascularization • photodynamic therapy 
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