May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Expression of Tissue Factor in Choroidal Melanoma and Its Clinical Significance
Author Affiliations & Notes
  • Y. Liu
    Dept. of Ophthalmology, West China Hosp-Sichuan Univ, Chengdu, China
  • M. X. Zhang
    Dept. of Ophthalmology, West China Hosp-Sichuan Univ, Chengdu, China
  • D. Lan
    Dept. of Ophthalmology, West China Hosp-Sichuan Univ, Chengdu, China
  • J. J. Zhang
    Dept. of Ophthalmology, West China Hosp-Sichuan Univ, Chengdu, China
  • Footnotes
    Commercial Relationships  Y. Liu, None; M.X. Zhang, None; D. Lan, None; J.J. Zhang, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 58. doi:https://doi.org/
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      Y. Liu, M. X. Zhang, D. Lan, J. J. Zhang; Expression of Tissue Factor in Choroidal Melanoma and Its Clinical Significance. Invest. Ophthalmol. Vis. Sci. 2008;49(13):58. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the expression of tissue factor (TF) in choroidal melanoma (CM) cell line and in human choroidal melanoma, and to study its specificity that can provide some evidence on therapy of CM.

Methods: : CM cells (OCM-1) were cultured in vitro and identified by observing the morphous.TF expression was studied with immunohistochemical staining method in OCM-1, and in specimens with 10 cases of CM and 5 cases of human normal choroidal tissue, with its clinic significance analyzed.

Results: : OCM-1 growth curve was similar to "S" type, which included the adaptive phase in first 12h, then entered into logarithmic growth phase, and finally into platform phase by 3d. TF protein was mainly expressed in cytoplasm of OCM-1 (positive cell percentage 85.33%±5.47%). Among 10 human choroidal melanoma tissue, TF protein was mainly expressed in cytoplasm of CM cell cytoplasm (positive cell percentage 41.60%±14.17%, IOD 33853.67±16445.30). Among 5 human normal choroidal tissue, TF protein was negative expressed.

Conclusions: : The result suggested TF peculiarly expressed in both CM cell line and human choroidal melanoma tissue may play a role as an immunotherapy target of CM, and provided some evidence on target-therapy of CM.

Keywords: choroid • tumors • immunohistochemistry 
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