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R. Trikha, L. S. Morse, J. Ryu, D. G. Telander, S. S. Park; Long-Term Follow Up Data on Subjects Treated Eith Fractionated External Beam Radiation for Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):585.
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To obtain long-term follow-up data on subjects treated with stereotactic fractionated external beam radiation (St-EBR) for age-related macular degeneration (AMD).
Retrospective chart review of subjects treated with St-EBR from 1997 to 2000 for neovascular AMD with doses ranging from 20 to 40 Gy , given in 200 cGy fractions.
Among 94 eyes treated, long-term follow-up data (mean 8.2 yrs, range 6 to 9.5 yrs) was available in 12 eyes from 11 subjects (mean age 82.6, range 69 to 91). Final visual acuity ranged from 20/50 to no light perception. Geographic atrophy was noted in 7 eyes (64%). Mild radiation retinopathy developed in 1 eye 6.5 yrs after 40Gy treatment. Among 2 eyes of patients that developed neovascular glaucoma, 5.25 yrs and 6 yrs after St-EBR, one patient developed diabetes mellitus and had concurrent diabetic retinopathy. The other suffered a massive postoperative suprachoroidal hemorrhage prior to developement of neovascular glaucoma.
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