May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Long-Term Follow Up Data on Subjects Treated Eith Fractionated External Beam Radiation for Neovascular Age-Related Macular Degeneration
Author Affiliations & Notes
  • R. Trikha
    UC Davis Medical Center, Sacramento, California
    Ophthalmology and Vision Science,
  • L. S. Morse
    UC Davis Medical Center, Sacramento, California
    Ophthalmology and Vision Science,
  • J. Ryu
    UC Davis Medical Center, Sacramento, California
    Radiation Oncology,
  • D. G. Telander
    UC Davis Medical Center, Sacramento, California
    Ophthalmology and Vision Science,
  • S. S. Park
    UC Davis Medical Center, Sacramento, California
    Ophthalmology and Vision Science,
  • Footnotes
    Commercial Relationships  R. Trikha, None; L.S. Morse, None; J. Ryu, None; D.G. Telander, None; S.S. Park, Genentech, F; Allergan, F; Oraya, C; Eyetech / OSI, C.
  • Footnotes
    Support  Research to Prevent Blindness Departmental Research Fund
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 585. doi:
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    • Get Citation

      R. Trikha, L. S. Morse, J. Ryu, D. G. Telander, S. S. Park; Long-Term Follow Up Data on Subjects Treated Eith Fractionated External Beam Radiation for Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2008;49(13):585.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To obtain long-term follow-up data on subjects treated with stereotactic fractionated external beam radiation (St-EBR) for age-related macular degeneration (AMD).

Methods: : Retrospective chart review of subjects treated with St-EBR from 1997 to 2000 for neovascular AMD with doses ranging from 20 to 40 Gy , given in 200 cGy fractions.

Results: : Among 94 eyes treated, long-term follow-up data (mean 8.2 yrs, range 6 to 9.5 yrs) was available in 12 eyes from 11 subjects (mean age 82.6, range 69 to 91). Final visual acuity ranged from 20/50 to no light perception. Geographic atrophy was noted in 7 eyes (64%). Mild radiation retinopathy developed in 1 eye 6.5 yrs after 40Gy treatment. Among 2 eyes of patients that developed neovascular glaucoma, 5.25 yrs and 6 yrs after St-EBR, one patient developed diabetes mellitus and had concurrent diabetic retinopathy. The other suffered a massive postoperative suprachoroidal hemorrhage prior to developement of neovascular glaucoma.

Keywords: age-related macular degeneration • radiation therapy 
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