May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Four-Year Incidence of Age-Related Macular Degeneration (AMD) in a Population-Based Cohort of Adult Latinos: The Los Angeles Latino Eye Study (LALES)
Author Affiliations & Notes
  • A. W. Foong
    University of Southern California, Los Angeles, California
    Ophthalmology,
  • M.-Y. Lai
    University of Southern California, Los Angeles, California
    Preventive Medicine,
  • J. Chung
    University of Southern California, Los Angeles, California
    Preventive Medicine,
  • R. Klein
    Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin
  • S. P. Azen
    University of Southern California, Los Angeles, California
    Preventive Medicine,
  • R. Varma
    University of Southern California, Los Angeles, California
    Ophthalmology,
  • the Los Angeles Latino Eye Study Group
    University of Southern California, Los Angeles, California
  • Footnotes
    Commercial Relationships  A.W. Foong, None; M. Lai, None; J. Chung, None; R. Klein, None; S.P. Azen, None; R. Varma, None.
  • Footnotes
    Support  NEI grants EY-11753 and EY-03040, and unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 596. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      A. W. Foong, M.-Y. Lai, J. Chung, R. Klein, S. P. Azen, R. Varma, the Los Angeles Latino Eye Study Group; Four-Year Incidence of Age-Related Macular Degeneration (AMD) in a Population-Based Cohort of Adult Latinos: The Los Angeles Latino Eye Study (LALES). Invest. Ophthalmol. Vis. Sci. 2008;49(13):596. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To evaluate the 4-year incidence of early (defined by drusen size and type and retinal pigmentary abnormalities) and advanced AMD (defined by geographic atrophy and exudative AMD) in a population-based sample of Latinos.

Methods: : Data for this analysis is derived from the Los Angeles Latino Eye Study (LALES), a population-based cohort study of eye disease in Latinos (primarily Mexican-Americans) aged 40 years and older. All participants underwent comprehensive ophthalmologic examination including stereoscopic fundus photography using standard protocols at both baseline and 4-year follow-up. Photographs were graded for AMD characteristics using a modified Wisconsin Age-Related Maculopathy Grading System. Incidence of AMD was defined by the Age-Related Eye Disease Study (AREDS) severity scale. Test of trend was conducted to assess differences in incidence when stratified by age groups and chi-square test for differences in incidence between genders.

Results: : The 4-year incidence of early AMD was 6.9% (95% CI, 6.0-7.9) [incidence for large drusen ≥125µm in diameter was 3.9% (95% CI, 3.4-4.4), soft distinct drusen was 10.4% (95% CI, 9.3-11.7), soft indistinct drusen was 2.0% (95% CI, 1.5-2.6), and pigmentary abnormalities was 2.1% (95% CI, 1.6-2.7)]. The 4-year incidence of advanced AMD was 0.2% (95% CI, 0.1-0.4) [incidence for geographic atrophy was 0.1% (95% CI, 0.0-0.3) and exudative AMD was 0.1% (95% CI, 0.0-0.3)]. Incidence increased with age for early AMD (from 4.0% in those 40-49 years of age to 15.8% in those over 70 years of age, p<0.001) and advanced AMD (from 0.2% in those 60-69 years of age to 6.3% in those over 70 years of age, p<0.001). There were no cases of incident advanced AMD in persons younger than 60 years of age. When controlling for age, there was no difference in incidence by gender.

Conclusions: : Data from this study described the low incidence of advanced AMD development in the Latino population. The reasons for lower age-specific incidence in Latinos compared to non-Hispanic Whites requires further epidemiological study.

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: prevalence/incidence 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×