May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Temporal Relationship Between Different Measures oVisual Function in Patients With Neovascular Macular Degeneration Treated With Photodynamic Therapy
Author Affiliations & Notes
  • K. Mandal
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • A. C. Fisher
    Department of Clinical Engineering, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • V. J. Tompkin
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • A. P. Tompkin
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • S. Murjaneh
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • N. Collaer
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • P. M. Lenfestey
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • I. A. Pearce
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • M. C. Briggs
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • S. P. Harding
    Clinical Eye Research Centre, St Paul's Eye Unit, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool L7 8XP, United Kingdom
  • Footnotes
    Commercial Relationships  K. Mandal, None; A.C. Fisher, None; V.J. Tompkin, None; A.P. Tompkin, None; S. Murjaneh, None; N. Collaer, None; P.M. Lenfestey, None; I.A. Pearce, None; M.C. Briggs, None; S.P. Harding, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 600. doi:https://doi.org/
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      K. Mandal, A. C. Fisher, V. J. Tompkin, A. P. Tompkin, S. Murjaneh, N. Collaer, P. M. Lenfestey, I. A. Pearce, M. C. Briggs, S. P. Harding; Temporal Relationship Between Different Measures oVisual Function in Patients With Neovascular Macular Degeneration Treated With Photodynamic Therapy. Invest. Ophthalmol. Vis. Sci. 2008;49(13):600. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Distance vision (DV), near vision (NV) and contrast sensitivity (CS) are important measures of vision used in the monitoring of patients with macular disease. The aim of this study was to determine the relationship over time in a group of patients with neovascular macular degeneration (nMD) being treated with photodynamic therapy (PDT).

Methods: : Patients attending a regional centre for treatment of nMD with PDT were recruited and followed at approximately 3 monthly intervals. Refraction protocol: best-corrected DV, NV and CS were measured by accredited testers using 2m logMAR, 25cm logMAR and 1m Pelli-Robson charts respectively using standard illumination. Patient data were represented by least squares polynomials of order 2, evaluated by interpolation over the intervals (0 2 4 6 8 10 12 14 16 18) months and summarised as ensemble averages, with weighting in local n to allow for censoring, for far, near and contrast over the interval of 0 to 12 months.

Results: : Data were available on patients commencing treatment between 1999 and 2006; DV:n=400, NV: n=363, CS: n=372. Average follow-up was 400 days. Average scores changed over the follow-up period as follows; DV: 48 to 39, NV: 1.05 to 1.20, CS: 23 to 23.2

Conclusions: : At presentation, patients with nMD are borderline visually impaired and steadily lose moderate amounts of DV during the 400 days of follow-up during a course of PDT. NV deteriorates slightly from the poor level at presentation. In contrast, CS is preserved at a fair level throughout.

Keywords: photodynamic therapy • age-related macular degeneration • low vision 
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