May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Multifactorial Influence on Macular Pigment in Healthy Individuals Evaluated by Food Frequency Questionnaire Bern (ffq Bern)
Author Affiliations & Notes
  • C. K. Brinkmann
    Klinik und Poliklinik für Augenheilkunde, Inselspital, University of Bern, Bern, Switzerland
  • S. P. Rothenbuehler
    Klinik und Poliklinik für Augenheilkunde, Inselspital, University of Bern, Bern, Switzerland
  • S. Wolf
    Klinik und Poliklinik für Augenheilkunde, Inselspital, University of Bern, Bern, Switzerland
  • U. E. K. Wolf-Schnurrbusch
    Klinik und Poliklinik für Augenheilkunde, Inselspital, University of Bern, Bern, Switzerland
  • Footnotes
    Commercial Relationships  C.K. Brinkmann, None; S.P. Rothenbuehler, None; S. Wolf, None; U.E.K. Wolf-Schnurrbusch, None.
  • Footnotes
    Support  SNF 3200Bo-109962/1 and Velux 303
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 604. doi:https://doi.org/
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      C. K. Brinkmann, S. P. Rothenbuehler, S. Wolf, U. E. K. Wolf-Schnurrbusch; Multifactorial Influence on Macular Pigment in Healthy Individuals Evaluated by Food Frequency Questionnaire Bern (ffq Bern). Invest. Ophthalmol. Vis. Sci. 2008;49(13):604. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Macular Pigment (MP) may have protective qualities against age-related macular degeneration (ARMD). Its major constituents Lutein and zeaxanthin (L&Z) are essential micronutrients. We evaluated the coherence of MP density and distribution with dietary habits, individual predisposition, lifestyle factors and family history.

Methods: : Prospective, cross sectional study on healthy individuals. Macular Pigment density (MPD) was measured using two wavelength autofluorescence by a modified scanning laser ophthalmoscope (SLO). Influential factors were noted on our 35-item food frequency questionnaire (ffq-Bern). Coherence analyses were performed graphically and by univariate testing (ANOVA).

Results: : We included 156 healthy subjects (101 f, 55 m, mean age: 44±19 years). MPD was normally distributed measuring 0.47±0.16 DU (density units). MPD was significantly low in coherence to obesity, positive family history for ARMD, and low daily intake of L&Z (p<0.05). We found tendencies for low MPD when there was low intake of polyunsaturated fatty acids (PUFA) and dark iris color, however statistically not significant (p<0.10). High sunlight exposure, smoking, age and gender had no significant influence on MPD (p>0.10).

Conclusions: : We were able to trace individual factors that are connected to low MP. Screening for these by ffq-Bern may set reference for ARMD protection by nutritional supplementation.

Clinical Trial: : www.clinicaltrials.gov NCT00494325 KEK 73/05 Ethikkomission Bern

Keywords: macular pigment • nutritional factors • lipids 
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