May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Visual Function and Tear Film Lipid Layer Stability in Patients With Dry Eye
Author Affiliations & Notes
  • S. Barabino
    Ocular Surface Research Center, Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Genoa, Italy
  • F. Allavena
    Ocular Surface Research Center, Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Genoa, Italy
  • C. Valente
    Ocular Surface Research Center, Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Genoa, Italy
  • M. Mete
    Ocular Surface Research Center, Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Genoa, Italy
  • M. Rolando
    Ocular Surface Research Center, Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Genoa, Italy
    IS.PRE Oftalmica, Genoa, Italy
  • Footnotes
    Commercial Relationships  S. Barabino, None; F. Allavena, None; C. Valente, None; M. Mete, None; M. Rolando, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 79. doi:https://doi.org/
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    • Get Citation

      S. Barabino, F. Allavena, C. Valente, M. Mete, M. Rolando; Visual Function and Tear Film Lipid Layer Stability in Patients With Dry Eye. Invest. Ophthalmol. Vis. Sci. 2008;49(13):79. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To test the hypothesis that patients with keratoconjunctivitis sicca (KCS) have a significant degree of visual function alterations and tear film lipid layer changes.

Methods: : Thirty patients (30 eyes) with dry eyes were identified on the basis of the typical symptoms measured by a validated questionnaire (OSDI Questionnaire Score >10), Schirmer I test scores < 10 mm/5 minutes, tear break-up time (BUT) < 7 seconds, lissamine green conjunctival staining > 3 (NEI grading system), and punctuate epithelial keratopathy. The dynamic lipid interference pattern test (DLIP) was used to measure tear lipid layer stability. Visual function was measured as distance contrast sensitivity by a letter chart, as near contrast sensitivity by means of a new test specifically developed for dry eyes, and by using a visual tracing test. A group of 30 healthy subjects (30 eyes) was used as control.

Results: : The DLIP test in the dry eye group (2.7 ± 2.0 blinks) was statistically decreased compared to the control group (17.8 ± 5.8 blinks, p< 0.0001, t-test). Patients with KCS showed a significant decrease of distance (p < 0.05) and near (p < 0.001) spatial-contrast sensitivity. A significant Pearson’s correlation (r = 0.61) was found between near spatial-contrast sensitivity and BUT. No differences were recorded in visual tracing tests performances.

Conclusions: : Tear film lipid layer changes and visual function alterations are characteristic of dry eye. Contrast sensitivity tests seem to be an important tool in our hands to measure quality of vision in KCS patients.

Keywords: cornea: tears/tear film/dry eye 
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