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D. R. Korb, C. A. Blackie, L. E. Paul, J. D. Solomon; Distribution of Meibomian Glands Yielding Liquid Secretion by Section of the Lower Lid. Invest. Ophthalmol. Vis. Sci. 2008;49(13):85.
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© ARVO (1962-2015); The Authors (2016-present)
The goal of this study was to determine the distribution , by section of the lower lid, of meibomian glands yielding liquid secretion of a broad spectrum of individuals. A secondary objective was to determine if the number of meibomian glands yielding liquid secretion is correlated to subjective symptoms.
133 subjects, 90 females and 43 males were selected for the study (age range was 18-82 yrs, mean 50.28 ± 14.7 yrs). The sample included those with and without dry eye symptoms, scored using the SPEED questionnaire. A standardized technique was used to perform the lower lid MG evaluations. Only one examiner performed all of the evaluations. The lower lid was evaluated in thirds: temporal, central and nasal.
The mean number of meibomian glands yielding liquid secretion (MGYLS) in each third of the lower lid was not significantly different between right and left eyes. Thus, these data were averaged for the analyses. The mean numbers of MGYLS in the temporal, central and nasal thirds of the lower lid are as follows: temporal = 0.27 ± 0.06, central = 2.14 ± 0.13 and nasal = 3.10 ± 0.15. The number of MGYLS was significantly lower in the temporal thirds of the lower lids compared with the central, p < 0.0001, and nasal thirds, p < 0.0001. Individuals were grouped into symptom categories for further analysis: mild, SPEED <= 5; moderate, SPEED = 6-9; and severe, SPEED >= 10. The number of MGYLS in the nasal and central regions of the lower lid was significantly lower in those with severe symptoms compared to those with minimal symptoms (nasal region, p = 0.0034, and central region, p = 0.0011). The total number of MGYLS in the lower lid was negatively correlated with symptom scores using the SPEED questionnaire, p = 0.0002.
This is the first report to document the distribution of meibomian glands yielding liquid secretion classified by their placement in the temporal, central or nasal section of the lower lid. This is also the first report correlating symptoms to the number of meibomian glands yielding liquid secretion in the lower lid.
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