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J. Chou, C. Reilly; Wavefront Higher Order Aberrations in Anisometropia. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1027.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the relationship between lower and higher order aberrations in anisometropia
This is a retrospective study of data gathered from Wavefront analysis at the Air Force Warfighter Refractive Center. The data was recorded between January 2002 and May 2006 and included 31,000 records. The data was analyzed to select 71 patients who had a greater than 2.0 diopter spherical equivalent difference between eyes and pupil size from 5 and 6 mm. Each record included higher order root mean square values for each eye. The 71 patient’s data were analyzed by comparing the difference in the spherical equivalence with the difference in the higher order aberration root mean square (HOA RMS).
Of the 71 patients in the study with greater than 2.0 diopter spherical equivalent differences, the differences in spherical equivalent ranged from 2.05 to 6.47 diopters. There were 39 (55%) patients with less than 3.0 diopter difference, 32 (45%) patients with greater than 3.0 diopter difference, and of those there are 11 (15%) patients with greater than 4.0 diopter difference. The Pearson correlation between the difference in HOA RMS and the difference in spherical equivalence was 0.141 p: 0.242. T-test with variable 1 as less than 3.0 diopter spherical equivalence and variable 2 as greater than 3.0 diopter spherical equivalence showed a significant difference in the mean difference in higher order aberration root mean square p = 0.048. Further analysis of correlations between difference in spherical equivalence and each Zernicke value found a statisical significance in Z4, Z23, and Z24 which are defocus, tertiary astigmatism, and secondary spherical respectively.
There is a statistically significant difference in the difference of the higher order aberration root mean square in those with greater than 3.0 diopter spherical equivalence difference interocularly when compared to those with less than 3.0 diopter spherical equivalence difference.
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