May 2008
Volume 49, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2008
Curvature Gradient and Corneal Remodeling
Author Affiliations & Notes
  • R. Vinciguerra
    Medicine, University of Milan, Milan, Italy
  • C. J. Roberts
    Ophthalmology and Biomedical Engineering, The Ohio State University, Columbus, Ohio
  • A. M. Mahmoud
    Ophthalmology and Biomedical Engineering, The Ohio State University, Columbus, Ohio
  • P. Vinciguerra
    Ophthalmology, Istituto Clinico Humanitas, Milan, Italy
  • Footnotes
    Commercial Relationships  R. Vinciguerra, None; C.J. Roberts, None; A.M. Mahmoud, None; P. Vinciguerra, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1044. doi:https://doi.org/
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    • Get Citation

      R. Vinciguerra, C. J. Roberts, A. M. Mahmoud, P. Vinciguerra; Curvature Gradient and Corneal Remodeling. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1044. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : to evaluate a new curvature gradient map to predict post operative corneal remodeling.

Methods: : : Two groups of post-excimer ablation surgery were retrospectively evaluated; the first group consisted of 32 eyes of 16 myopic subjects and the second consisted of 6 eyes of 4 astigmatic subjects. The new curvature gradient map, implemented on the CSO Corneal Topographer (Florence, Italy), acquired immediately post-operatively was compared to the tangential curvature difference map between 1 and 12 months to determine the relationship. Corneas were divided into 12 regions for analysis: four 90º wide sectors centered on 0º, 90º, 180º, and 270º, with 3 subdivisions in each sector; from a radius of 0-2.75mm (central), from a radius of 2.75-3.25mm (paracentral), and from a radius of 3.25-4.5mm (peripheral). Linear regression analysis was performed by region, comparing the immediate post-op gradient map to the tangential curvature difference between 1 and 12 months.

Results: : In the myopic group, the following regions a had significant relationship between the initial curvature gradient and the curvature difference between 1 and 12 months: the paracentral zone of the 90º sector (p=0.0145, R2 = 0.1832) and both the central (p= 0.0034, R2 = 0.2522) and paracentral (p= 0.0452, R2 = 0.1271) zones of the 270 º sector. The greatest average initial tangential curvature was present in the 270 º sector. In the astigmatic group, the following regions had a significant relationship: both the central zone (p= 0.0033, R2 = 0.9476) and peripheral zone (p= 0.0003, R2 = 0.9891) of the 0º sector, as well as the peripheral zone of the 90º sector (p= 0.0303, R2 = 0.7786).

Keywords: topography • adaptation: pattern • cornea: epithelium 
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