May 2008
Volume 49, Issue 13
ARVO Annual Meeting Abstract  |   May 2008
Short- and Long-Term IOP Fluctuations in Patients With Ocular Hypertension, Stable Glaucoma and Progressing Glaucoma
Author Affiliations & Notes
  • L. Rossetti
    Eye Clinic, University of Milan, Milan, Italy
  • P. Fogagnolo
    G.B. Bietti Foudation – IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy
  • M. Centofanti
    Eye Clinic, University of Tor Vergata, Rome, Italy
  • F. Oddone
    G.B. Bietti Foudation – IRCCS, Rome, Italy
  • M. Sacchi
    Eye Clinic, University of Milan, Milan, Italy
  • A. Ferreras
    Eye Clinic, Miguel Servet University Hospital, Zaragoza, Spain
  • N. Orzalesi
    Eye Clinic, University of Milan, Milan, Italy
  • Footnotes
    Commercial Relationships  L. Rossetti, None; P. Fogagnolo, None; M. Centofanti, None; F. Oddone, None; M. Sacchi, None; A. Ferreras, None; N. Orzalesi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1053. doi:
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      L. Rossetti, P. Fogagnolo, M. Centofanti, F. Oddone, M. Sacchi, A. Ferreras, N. Orzalesi; Short- and Long-Term IOP Fluctuations in Patients With Ocular Hypertension, Stable Glaucoma and Progressing Glaucoma. Invest. Ophthalmol. Vis. Sci. 2008;49(13):1053. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : . To assess and compare short (STF) and long-term (LTF) IOP fluctuations in patients with glaucoma or ocular hypertension (OH).

Methods: : . This is a retrospective analysis of prospective data from a randomized clinical trial; it evaluated 19 patients with OH, 24 patients with stable primary open-angle glaucoma (SG), and 28 patients with progressing disease (PG). Patients underwent a circadian 24-h Goldmann IOP curve (measurements at 8 pm, midnight, 4 am, 8 am, noon, and 4 pm) at baseline, and follow-up visits with visual field repetitions every 6 months for at least 2 years. Each patient maintained the same IOP-lowering regimen throughout follow-up. Progression was based on perimetric changes: worsening of any index probability, development or deepening of scotomas. STF was calculated as the standard deviation of the 24-h IOP values; LTF as the standard deviation of IOP readings at follow-up visits. The percentage of follow-up IOP readings exceeding the individual upper-95%CI of STF was calculated.

Results: : . STF and LTF for OH, SG, and PG were respectively: 2.0±0.6 and 2.0±0.9, 2.3±1.2 and 1.8±0.8, and 1.6±0.6 and 2.1±0.8 (P>0.05 comparing STF and LTF between all groups). At follow-up, a mean of 44% IOP readings exceeded the upper-95%CI of STF for PG, compared to 15% for both OH and SG (P<0.001); mean IOP remained stable during the study for OH and SG, while it increased by 1 mmHg in PG (P<0.001).

Conclusions: : . At follow-up, PG showed both higher IOP readings and a higher number of IOP readings exceeding STF compared to OH and SG.

Keywords: intraocular pressure 

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